Cochrane · systematic review · CD005364
Topical anaesthetics for pain control during repair of dermal laceration
Tayeb, BO, Eidelman, A, Eidelman, CL, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 1 · 14.3%Very low 0 · 0%Low 6 · 85.7%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 2 versionsPrimary outcome: topical local anaesthetics compared with infiltrated local anaesthetics or other topical agents for repair of dermal lacerations
Population: adults and paediatric patients with dermal laceration
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain intensity measures Cocaine‐containing topical anaesthetics vs infiltrated local anaesthetics Primary outcome: topical local anaesthetics vs infiltrated local anaesthetics or other topical agents | no estimate extracted | 6 studies · 1006 participants | Low Downgraded: risk of bias |
Pain intensity measures Comparisons between different cocaine‐containing topical anaesthetics Primary outcome: topical local anaesthetics vs infiltrated local anaesthetics or other topical agents | no estimate extracted | 4 studies · 530 participants | Low Downgraded: risk of bias |
Pain intensity measures Cocaine‐free topical anaesthetics compared with infiltrated local anaesthetics Primary outcome: topical local anaesthetics vs infiltrated local anaesthetics or other topical agents | no estimate extracted | 6 studies · 543 participants | Low Downgraded: risk of bias |
Pain intensity measures Cocaine‐fee topical anaesthetics compared with cocaine‐containing topical anaesthetics Primary outcome: topical local anaesthetics vs infiltrated local anaesthetics or other topical agents | no estimate extracted | 11 studies · 1231 participants | Low Downgraded: risk of bias |
Pain intensity measures Comparisons between different cocaine‐free topical anaesthetics Primary outcome: topical local anaesthetics vs infiltrated local anaesthetics or other topical agents | no estimate extracted | 5 studies · 656 participants | Low Downgraded: risk of bias |
Anaesthetic‐related adverse effects Primary outcome: topical local anaesthetics vs infiltrated local anaesthetics or other topical agents | RR 0 [0, 0] | 11 studies · 1686 participants | Ungraded |
Primary outcome subanalysis: pain intensity measures of topical prilocaine‐phenylephrine (PP) and topical tetracaine‐epinephrine‐cocaine (TAC)
Population: treatment repair of dermal laceration
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Participant self‐reported VAS (0‐100 mm) pain scores | no estimate extracted | 2 studies · 240 participants | Low Downgraded: risk of bias |