Cochrane · systematic review · CD011940
Adverse side effects of dexamethasone in surgical patients
Polderman, JAW, Farhang‐Razi, V, Van Dieren, S, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
4
current version
GRADE rated
4
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 25%Low 2 · 50%Moderate 1 · 25%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 2 versionsDexamethasone compared to control in surgical patients
Population: surgical patients undergoing various types of surgery (e.g. abdominal, brain, cardiac, and orthopaedic surgery)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Postoperative wound or systemic infection Dexamethasone vs control | OR 1.01 [0.8, 1.27] | 26 studies · 4603 participants | Moderate Downgraded: risk of bias, imprecision |
Delayed wound healing Dexamethasone vs control | OR 0.99 [0.28, 3.43] | 8 studies · 642 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Glycaemic response ‐ change from baseline to 2 to 12 hours postoperatively in patients without diabetes Dexamethasone vs control | no estimate extracted | 10 studies · 595 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Glycaemic response ‐ change from baseline to 10 to 24 hours after surgery in patients with diabetes Dexamethasone vs control | no estimate extracted | 2 studies · 74 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |