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Evidence found and GRADE certainty

3,092 questions · 3,199 findings · 339 reviews · Headline outcomes only

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No studies found 714 · 22.3%GRADE not reported 181 · 5.7%Very low 695 · 21.7%Low 908 · 28.4%Moderate 568 · 17.8%High 133 · 4.2%

Oral vs IV followed by oral (11 days) therapy

Renal parenchymal damage at 6 to 12 months: all included children with acute pyelonephritis DMSA scans · children with acute pyelonephritis

Oral showed no clear difference in renal parenchymal damage at 6 to 12 months: all included children… compared with IV followed by oral (11 days) therapy (moderate certainty).

1 finding from 1 review

Oral vs IV followed by oral (11 days) therapy

Renal parenchymal damage at 6 to 12 months: children with renal parenchymal damage on initial DMSA · children with acute pyelonephritis

Oral showed no clear difference in renal parenchymal damage at 6 to 12 months: children with renal… compared with IV followed by oral (11 days) therapy (moderate certainty).

1 finding from 1 review

Combined oral and intravenous vs oral or intravenous alone

Wound infection · colorectal surgery

Combined oral and intravenous leads to lower surgical wound infection: oral + iv versus iv alone compared with oral or intravenous alone (high certainty).

2 findings from 1 review

Oral vs intra‐vaginal antifungal treatment of uncomplicated vulvovaginal candidiasis

Clinical cure · women aged 16 and over with uncomplicated vulvovaginal candidiasis

Oral showed no clear difference in clinical cure (short term: 5 to 15 days) compared with intra‐vaginal antifungal treatment of uncomplicated vulvovaginal… (moderate certainty).

2 findings from 1 review

Oral vs intra‐vaginal antifungal treatment of uncomplicated vulvovaginal candidiasis

Mycological cure · women aged 16 and over with uncomplicated vulvovaginal candidiasis

Oral probably leads to higher mycological cure (short term; 5 to 15 days) compared with intra‐vaginal antifungal treatment of uncomplicated vulvovaginal… (moderate certainty).

2 findings from 1 review

Oral vs intra‐vaginal antifungal treatment of uncomplicated vulvovaginal candidiasis

Side effects (patient‐reported side effects) · women aged 16 and over with uncomplicated vulvovaginal candidiasis

Oral may leads to higher side effects (patient‐reported side effects) compared with intra‐vaginal antifungal treatment of uncomplicated vulvovaginal… (low certainty).

1 finding from 1 review