Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

13 questions · 15 findings · 9 reviews · Musculoskeletal · Headline outcomes only

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 4 · 26.7%Low 6 · 40%Moderate 5 · 33.3%High 0 · 0%

Belimumab 10 mg/kg vs placebo

Participants with one or more serious adverse events · people with active systemic lupus erythematosus (but not active nephritis or active central nervous system involvement)

Belimumab 10 mg/kg showed no clear difference in participants with one or more serious adverse events compared with placebo (low certainty).

1 finding from 1 review

Belimumab 10 mg/kg vs placebo

Participants with one or more serious infections · people with active systemic lupus erythematosus (but not active nephritis or active central nervous system involvement)

Belimumab 10 mg/kg showed no clear difference in participants with one or more serious infections compared with placebo (moderate certainty).

1 finding from 1 review

Exercise vs no exercise

Pain ‐ long term (12 months and beyond) Pain subscale of Michigan Hand Outcomes Questionnaire (0 to 100 points, higher score means more pain) · rheumatoid arthritis of the hand
1 finding from 1 review

Open surgery vs steroid injection

Resolution of symptoms · patients with trigger finger

It is very uncertain whether open surgery changes resolution of symptoms (after one or more injections) compared with steroid injection (very low certainty).

1 finding from 1 review

Percutaneous surgery vs steroid injection

Resolution of symptoms · patients with trigger finger

It is very uncertain whether percutaneous surgery changes resolution of symptoms (after 1 or more injections) compared with steroid injection (very low certainty).

1 finding from 1 review

Additional radon in carbon dioxide baths vs carbon dioxide baths only

Improvement More than 1 category change in pain intensity on 4‐point scale (no pain/sporadic/daily/continuous) · patients with rheumatoid arthritis

Additional radon in carbon dioxide baths showed no clear difference in improvement More than 1 category change in pain intensity on 4‐point… compared with carbon dioxide baths only (low certainty).

2 findings from 1 review