Belimumab 10 mg/kg vs placebo: Participants with one or more serious infections
Belimumab 10 mg/kg showed no clear difference in participants with one or more serious infections compared with placebo (moderate certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Belimumab 10 mg/kg vs placebo Participants with one or more serious infections · people with active systemic lupus erythematosus (but not active nephritis or active central nervous system involvement) Belimumab 10 mg/kg showed no clear difference in participants with one or more serious infections compared with placebo (moderate certainty). Belimumab for systemic lupus erythematosus (2021) · Cochrane Headline outcomes only | RR 1.01 [0.66, 1.54] | 4 studies · 2185 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Belimumab for systemic lupus erythematosus 2021 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.