Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

65 questions · 65 findings · 32 reviews · Airways · Headline outcomes only

No studies found 4 · 6.2%GRADE not reported 1 · 1.5%Very low 8 · 12.3%Low 18 · 27.7%Moderate 26 · 40%High 8 · 12.3%

Antibiotics vs placebo

Exacerbations · Adults (aged 40 or over) with COPD presenting with 1 or more exacerbations in the previous year. The 2 larger studies (Albert 2011; Sethi…

Antibiotics probably leads to lower number of people with one or more exacerbations WMD of compared with placebo (moderate certainty).

1 finding from 1 review

Vitamin D vs placebo

Rate of exacerbations requiring systemic corticosteroids · children and adults with predominantly mild to moderate asthma

Summary of findings table ‐ Vitamin D showed no clear difference in proportion of participants with one or more exacerbations treated… compared with placebo (high certainty).

1 finding from 1 review

Vitamin D vs placebo

Patients with severe exacerbations (requiring hospitalisation or ER visit) · children and adults with predominantly mild to moderate asthma

Summary of findings table ‐ Vitamin D showed no clear difference in proportion of participants with one or more exacerbations requiring… compared with placebo (moderate certainty).

1 finding from 1 review

Vitamin D vs placebo

Proportion of participants with one or more serious adverse events due to any cause · children and adults with predominantly mild to moderate asthma

Summary of findings table ‐ Vitamin D showed no clear difference in proportion of participants with one or more serious adverse events… compared with placebo (high certainty).

1 finding from 1 review

Remote monitoring vs usual care

Exacerbations (number of people experiencing ≥ 1 exacerbations) · patients with chronic obstructive pulmonary disease

It is very uncertain whether remote monitoring changes number of people experiencing 1 or more exacerbations compared with usual care (very low certainty).

1 finding from 1 review

Remote monitoring plus usual care vs usual care

Exacerbations (number of people experiencing ≥ 1 exacerbations) · patients with chronic obstructive pulmonary disease

It is very uncertain whether remote monitoring plus usual care changes number of people experiencing 1 or more exacerbations compared with usual care (very low certainty).

1 finding from 1 review

Multi‐component interventions (with telehealth as a component of care) vs usual care

Adverse events: number of people with 1 or more (all‐cause) · patients with chronic obstructive pulmonary disease

It is very uncertain whether multi‐component interventions (with telehealth as a component of care) changes adverse events: number of people with 1 or more (all‐cause) compared with usual care (very low certainty).

1 finding from 1 review

Intervention vs usual care

Exacerbations (number of people experiencing ≥ 1 exacerbations) · COPD and at least one other long‐term condition

It is very uncertain whether intervention changes exacerbations ‐ number of people experiencing one or more  compared with usual care (very low certainty).

1 finding from 1 review

Supervised maintenance programme following pulmonary rehabilitation vs usual care

Exacerbations (number of people experiencing ≥ 1 exacerbations) · patients with chronic obstructive pulmonary disease

Supervised maintenance programme following pulmonary rehabilitation showed no clear difference in exacerbation: number of people experiencing one or more exacerbation compared with usual care (low certainty).

1 finding from 1 review

PPI plus usual care vs usual care alone or chronic obstructive pulmonary disease

Exacerbations · patients with chronic obstructive pulmonary disease

PPI plus usual care may leads to lower exacerbation rate (participants with one or more) study duration: 12… compared with usual care alone or chronic obstructive pulmonary disease (low certainty).

1 finding from 1 review

Auto‐CPAP vs fixed CPAP

Number of participants using machine for 4 or more hours per night · adults with a diagnosis of OSA

Auto‐CPAP showed no clear difference in number of participants using machine for 4 or more hours per night compared with fixed CPAP (low certainty).

1 finding from 1 review

Macrolides vs tetracycline

Exacerbations (number of people experiencing ≥ 1 exacerbations) · patients with chronic obstructive pulmonary disease

Macrolide showed no clear difference in number of participants experiencing one or more exacerbations… compared with tetracycline (low certainty).

1 finding from 1 review