evidence/gaps
Cochrane · systematic review · CD013113

Proton pump inhibitors for chronic obstructive pulmonary disease

Kikuchi, S, Imai, H, Tani, Y, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library

AirwaysAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
2
No studies
4
Included studies
NR
No studies 4 · 66.7%Ungraded 0 · 0%Very low 1 · 16.7%Low 1 · 16.7%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

PPI plus usual care versus usual care alone or chronic obstructive pulmonary disease

Population: chronic obstructive pulmonary disease
6 questions
OutcomeEffectEvidenceStatus / GRADE
Exacerbation rate (participants with one or more) study duration: 12 months
PPI plus usual care vs usual care alone or chronic obstructive pulmonary disease
RR 0.46 [0.26, 0.81]1 study · 100 participantsLow
Downgraded: imprecision
Pneumonia and other serious adverse events
PPI plus usual care vs usual care alone or chronic obstructive pulmonary disease
no estimate extractedNRNo studies
Quality of life
PPI plus usual care vs usual care alone or chronic obstructive pulmonary disease
no estimate extractedNRNo studies
Lung function indices
PPI plus usual care vs usual care alone or chronic obstructive pulmonary disease
no estimate extractedNRNo studies
Acute respiratory infections study duration: 12 months
PPI plus usual care vs usual care alone or chronic obstructive pulmonary disease
RR 0.96 [0.67, 1.39]1 study · 100 participantsVery low
Downgraded: imprecision
Disease‐specific adverse events
PPI plus usual care vs usual care alone or chronic obstructive pulmonary disease
no estimate extractedNRNo studies