Participant‐reported pain relief of 30% or greater · adults with fibromyalgia
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Participant‐reported pain relief of 50% or greater · adults with fibromyalgia
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Patient Global Impression of Change much or very much improved · adults with fibromyalgia
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Any pain‐related outcome indicating some improvement · adults with fibromyalgia
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Number experiencing adverse effects · adults with fibromyalgia
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Number of participants experiencing any serious adverse events · adults with fibromyalgia
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Withdrawals due to adverse events · adults with fibromyalgia
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Any pain‐related outcome indicating some improvement · adults with neuropathic pain
1 finding from 1 review
Intervention not reported
Achievement of at least 50% reduction in headache severity Post‐treatment Higher scores indicate more children with reduced headache · children or adolescents with headaches
It is very uncertain whether the intervention changes achievement of at least 50% reduction in headache severity… (very low certainty).
1 finding from 1 review
Responder rate (achievement of at least 50% reduction in migraine frequency) Higher numbers mean more people responded · adults with migraine
It is very uncertain whether psychological therapies changes responder rate (achievement of at least 50% reduction in migraine… compared with controls (very low certainty).
1 finding from 1 review
Number of participants reporting an adverse event · adults with migraine
It is very uncertain whether psychological therapies changes adverse events (proportion of people reporting an adverse event)… compared with controls (very low certainty).
1 finding from 1 review
Participant‐reported sleep problems (scale: 0 to 28; higher scores indicate more sleep problems) · adults with fibromyalgia
Mirtazapine showed no clear difference in participant‐reported sleep problems (scale: 0 to 28; higher scores… compared with placebo (low certainty).
1 finding from 1 review
Quality of life SF‐36 bodily pain score (0‐100, lower score = more disability) · adults with neuropathic pain
1 finding from 1 review
Intervention not reported
Sleep problems (Scale 0 to 21; higher scores indicate more sleep problems) · adults with fibromyalgia
1 finding from 1 review
Participant‐reported sleep problems (scale: 0 to 28; higher scores indicate more sleep problems) · patients with fibromyalgia
1 finding from 1 review
Participant‐reported sleep problems (scale: 0 to 28; higher scores indicate more sleep problems) · patients with fibromyalgia
1 finding from 1 review
Intervention not reported
Total studies: 42 Total participants: 14,626 · people with chronic pain Interventions: desvenlafaxine high dose (≥ 50 mg); duloxetine low dose (< 60 mg), standard dose (60 mg), and high…
The intervention led to lower total studies: 42 Total participants: 14,626; GRADE not reported.
1 finding from 1 review
no estimate extracted
42 participants
GRADE not reported
Intervention not reported
Desvenlafaxine high dose RCTs: 2 Participants: 870 · people with chronic pain Interventions: desvenlafaxine high dose (≥ 50 mg); duloxetine low dose (< 60 mg), standard dose (60 mg), and high…
1 finding from 1 review
no estimate extracted
2 participants
Very low
Intervention not reported
Duloxetine standard dose RCTs: 16 Participants: 4490 · people with chronic pain Interventions: desvenlafaxine high dose (≥ 50 mg); duloxetine low dose (< 60 mg), standard dose (60 mg), and high…
1 finding from 1 review
no estimate extracted
16 participants
Moderate
Intervention not reported
Duloxetine high dose RCTs: 14 Participants: 3692 · people with chronic pain Interventions: desvenlafaxine high dose (≥ 50 mg); duloxetine low dose (< 60 mg), standard dose (60 mg), and high…
1 finding from 1 review
no estimate extracted
14 participants
Moderate