Periodontal disease - novel loci (meta-analysis) · Adults from Japanese and European cohorts (present study + GLIDE + UK Biobank + BioBank Japan); periodontal disease cases vs controls
The meta-analysis found no novel loci for periodontal disease; the European SIGLEC5/chr19 locus did not replicate in Japanese populations; ungraded.
1 finding from 1 review
Genome-wide association meta-analysis identifies two novel loci associated with dental caries. 2024 All outcomesLifelong (germline genotype) · Population-based genetic association study (Japanese + European cohorts) · Meta-analysis: present study + GLIDE + UKB + BBJ
Meta-analysis of periodontal disease identified only previously known loci; no novel loci. The chromosome-19 SIGLEC5 locus associated with periodontitis in Europeans was not replicated in Japanese populations (present…
4 studies · 764572 participants
GRADE not reported
Shear bond strength (SBS) of metallic orthodontic brackets · Extracted permanent human teeth (enamel); sound or demineralized
CPP-ACP enamel pre-treatment before bonding did not significantly affect the shear bond strength of metallic orthodontic brackets (MD 1.163 MPa, 95% CI -0.321 to 2.648; ungraded).
1 finding from 1 review
Shear bond strength (SBS) of metallic orthodontic brackets · Sound enamel of extracted permanent human teeth
When used to prevent white spot lesions on sound enamel, CPP-ACP pre-treatment did not significantly affect shear bond strength (MD 1.009, 95% CI -0.723 to 2.740; ungraded).
1 finding from 1 review
MD 1.009 [-0.723, 2.740]
7 studies
GRADE not reported
Shear bond strength (SBS) of metallic orthodontic brackets · Demineralized enamel of extracted permanent human teeth
When used to remineralize white spot lesions on demineralized enamel, CPP-ACP pre-treatment did not significantly affect shear bond strength (MD 1.501, 95% CI -0.630 to 3.632; ungraded).
1 finding from 1 review
MD 1.501 [-0.630, 3.632]
9 studies
GRADE not reported
Early childhood caries (ECC) · Children aged 0-5 years in North Africa
Tooth brushing method was associated with higher odds of ECC (OR 1.435).
1 finding from 1 review
OR 1.435 [1.207, 2.915]
1 study
GRADE not reported
Bridge failure · Adults (18 years or older) needing a three-unit fixed dental prosthesis (FDP)
1 finding from 1 review
Periodontal/peri-implant status (secondary outcomes) · Adults (18 years or older) needing a three-unit fixed dental prosthesis (FDP)
The review found no eligible studies for this question.
1 finding from 1 review
Bridge complications · Adults (18 years or older) needing a three-unit fixed dental prosthesis (FDP)
It is very uncertain whether metal-free FDPs (zirconia ceramic) changes bridge complications compared with metal-ceramic FDPs (very low certainty).
1 finding from 1 review
Patient satisfaction (measured by patient satisfaction or aesthetic scales) · Adults (18 years or older) needing a three-unit fixed dental prosthesis (FDP)
It is very uncertain whether metal-free FDPs (zirconia ceramic) changes aesthetic evaluation (patient aesthetic satisfaction changes) compared with metal-ceramic FDPs (very low certainty).
1 finding from 1 review
Aesthetics · Adults (18 years or older) needing a three-unit fixed dental prosthesis (FDP)
The review found no eligible studies for this question.
1 finding from 1 review
Bridge complications · Adults (18 years or older) needing a three-unit fixed dental prosthesis (FDP)
It is very uncertain whether metal-free FDPs (lithium disilicate) changes bridge complications compared with metal-ceramic FDPs (very low certainty).
1 finding from 1 review
Bridge failure · Adults (18 years or older) needing a three-unit fixed dental prosthesis (FDP)
It is very uncertain whether metal-free FDPs (lithium disilicate) changes bridge failure compared with metal-ceramic FDPs (very low certainty).
2 findings from 1 review
Periodontal/peri-implant status and occlusal wear (secondary outcomes) · Adults (18 years or older) needing a three-unit fixed dental prosthesis (FDP)
The review found no eligible studies for this question.
1 finding from 1 review
Marginal bone level change · Adults (18 years or older) with one missing tooth in the aesthetic zone needing an implant-supported single crown
Metal-free implant abutments (zirconia) showed no clear difference in marginal bone level change (MBLC) compared with metal implant abutments (titanium); GRADE not reported.
2 findings from 1 review
Periodontal or peri-implant status: gingival recession (REC) · Adults (18 years or older) with one missing tooth in the aesthetic zone needing an implant-supported single crown
Metal-free implant abutments (zirconia) showed no clear difference in gingival/mucosal recession (REC) compared with metal implant abutments (titanium); GRADE not reported.
1 finding from 1 review
Abutment failure · Adults (18 years or older) with one missing tooth in the aesthetic zone needing an implant-supported single crown
It is very uncertain whether metal-free implant abutments (zirconia) changes abutment failure compared with metal implant abutments (titanium) (very low certainty).
1 finding from 1 review
Implant probing pocket depth (PPD) · Adults (18 years or older) with one missing tooth in the aesthetic zone needing an implant-supported single crown
Metal-free implant abutments (zirconia) showed no clear difference in implant probing pocket depth (PPD) compared with metal implant abutments (titanium); GRADE not reported.
1 finding from 1 review
Complications · Adults (18 years or older) with one missing tooth in the aesthetic zone needing an implant-supported single crown
1 finding from 1 review
Aesthetics · Adults (18 years or older) with one missing tooth in the aesthetic zone needing an implant-supported single crown
1 finding from 1 review
Primary outcome aesthetic evaluation data were reported as the frequency of distribution of the Implant Crown Aesthetic Index (ICAI); no comparative summary estimate was presented.
2 studies · 47 participants
Very low
Crown failure · Adults (18 years or older) needing a single crown in the molar or premolar region
It is very uncertain whether metal-free single crowns (full-contour zirconia) changes crown failure compared with cast gold (conventional metal) single crowns (very low certainty).
2 findings from 1 review