Clinical pregnancy rate · women with polycystic ovary syndrome
It is very uncertain whether metformin changes clinical pregnancy rate per woman ‐ short protocol GnRH‐antagonist compared with placebo or no treatment (very low certainty).
Miscarriage · women with polycystic ovary syndrome
Metformin showed no clear difference in miscarriage rate per woman compared with placebo or no treatment (low certainty).
Live birth rate per woman aParticipants with BMI < 30 kg/m2 or ≤ 32 kg/m2 · women with polycystic ovary syndrome
It is very uncertain whether metformin changes live birth rate per woman aParticipants with BMI < 30 kg/m2 or ≤ 32… compared with clomiphene citrate (very low certainty).
Live birth rate per woman aParticipants with BMI ≥ 30 kg/m2 · women with polycystic ovary syndrome
It is very uncertain whether metformin changes live birth rate per woman aParticipants with BMI ≥ 30 kg/m2 compared with clomiphene citrate (very low certainty).
Gastrointestinal adverse events · women with polycystic ovary syndrome
The review found no eligible studies for this question.
no estimate extracted
Studies not reported
No studies found
no estimate extracted
Studies not reported
No studies found
Clinical pregnancy rate per woman Participants with BMI < 30 kg/m2 or ≤ 32 kg/m2a · women with polycystic ovary syndrome
Metformin may leads to higher clinical pregnancy rate per womanaParticipants with BMI < 30 kg/m2… compared with clomiphene citrate (low certainty).
Clinical pregnancy rate per woman aParticipants with BMI ≥ 30 kg/m2 · women with polycystic ovary syndrome
Metformin may leads to lower clinical pregnancy rate per woman aParticipants with BMI ≥ 30 kg/m2 compared with clomiphene citrate (low certainty).
Ovulation rate per woman fParticipants with BMI < 30 kg/m2 · women with polycystic ovary syndrome
Metformin showed no clear difference in ovulation rate per woman fParticipants with BMI < 30 kg/m2 compared with clomiphene citrate (low certainty).
Ovulation rate per woman fParticipants with BMI ≥ 30 kg/m2 · women with polycystic ovary syndrome
Metformin may leads to lower ovulation rate per woman fParticipants with BMI ≥ 30 kg/m2 compared with clomiphene citrate (low certainty).
Miscarriage · women with polycystic ovary syndrome
Metformin combined with clomiphene citrate showed no clear difference in miscarriage rate per woman compared with clomiphene citrate alone (low certainty).
Live birth rate per woman · women with polycystic ovary syndrome
Metformin combined with clomiphene citrate showed no clear difference in live birth rate per woman compared with clomiphene citrate alone (low certainty).
Gastrointestinal adverse events · women with polycystic ovary syndrome
Metformin combined with clomiphene citrate probably leads to higher adverse events (gastrointestinal) per woman compared with clomiphene citrate alone (moderate certainty).
Clinical pregnancy rate · women with polycystic ovary syndrome
Metformin combined with clomiphene citrate probably leads to higher clinical pregnancy rate per woman compared with clomiphene citrate alone (moderate certainty).
Ovulation rate · women with polycystic ovary syndrome
Metformin combined with clomiphene citrate may leads to higher ovulation rate per woman compared with clomiphene citrate alone (low certainty).
Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure
In partial pulpotomy, MTA had significantly higher success than calcium hydroxide (OR 2.81; ungraded).
Show 2 more findings
Dental caries · children
Maternal smoking during pregnancy was associated with higher odds of dental caries in children (OR 1.78, 95% CI 1.55 to 2.05; ungraded).
Show 11 more findings
OR 1.56 [1.46, 1.67]
2 studies
GRADE not reported
OR 1.68 [1.01, 2.79]
1 study
GRADE not reported
Correlation Between Maternal Smoking During Pregnancy and Dental Caries in Children: A Systematic Review and… 2021 All outcomesCommunity/population-based (multiple countries) · Caries assessment: clinical and radiographic examination
OR 1.56 [1.46, 1.67]
1 study
GRADE not reported
OR 1.61 [1.30, 2.01]
4 studies
GRADE not reported
OR 1.55 [1.45, 1.66]
3 studies
GRADE not reported
OR 1.71 [1.34, 2.16]
3 studies
GRADE not reported
Correlation Between Maternal Smoking During Pregnancy and Dental Caries in Children: A Systematic Review and… 2021 All outcomesCommunity/population-based (multiple countries) · Caries assessment: visual/tactile examination
OR 1.48 [1.15, 1.91]
3 studies
GRADE not reported
OR 1.57 [1.47, 1.67]
6 studies
GRADE not reported
OR 1.84 [1.39, 2.45]
2 studies
GRADE not reported
RR 1.26 [1.07, 1.48]
3 studies
GRADE not reported
OR 1.84 [1.39, 2.45]
2 studies
GRADE not reported
Relative abundance of Veillonella spp. · Young children with early childhood caries and caries-free controls
Veillonella spp. is more abundant in children with early childhood caries than in caries-free children (mean difference 2.22, 95% CI 0.54 to 3.90); very low certainty.
Adverse events · high‐grade glioma
The review found no eligible studies for this question.
no estimate extracted
Studies not reported
No studies found
Overall survival · high‐grade glioma
The review found no eligible studies for this question.
no estimate extracted
Studies not reported
No studies found
Progression‐free survival · high‐grade glioma
The review found no eligible studies for this question.
no estimate extracted
Studies not reported
No studies found