Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

131 questions · 132 findings · 48 reviews · Schizophrenia

No studies found 10 · 7.6%GRADE not reported 3 · 2.3%Very low 78 · 59.1%Low 28 · 21.2%Moderate 12 · 9.1%High 1 · 0.8%

Maintenance treatment with antipsychotic drugs vs placebo/no treatment

Acceptability of treatment ‐ leaving the study early · schizophrenia

Maintenance treatment with antipsychotic drugs leads to lower leaving the study early: due to any reason (acceptability of… compared with placebo/no treatment (high certainty).

1 finding from 1 review

Group C other: integrated treatment vs usual care

Satisfaction with treatment: leaving the study early Endpoint data (events) · people in the prodromal stage of psychosis

It is very uncertain whether group C other: integrated treatment changes satisfaction with treatment: leaving the study early Endpoint data… compared with standard treatment (very low certainty).

1 finding from 1 review

Lithium as sole treatment vs placebo

Acceptability ‐ total dropouts · schizophrenia

Lithium as sole treatment showed no clear difference in acceptability of treatment leaving early due to any reason compared with placebo (low certainty).

1 finding from 1 review

Group C other: family treatment vs enhanced care

Satisfaction with treatment: leaving the study early FACT Long‐term · people in the prodromal stage of psychosis

It is very uncertain whether group C other: family treatment changes satisfaction with treatment: leaving the study early FACT Long‐term compared with enhanced care (very low certainty).

1 finding from 1 review

BENZODIAZEPINES AS SOLE TREATMENT vs placebo

Unacceptability of treatment (drop-outs / leaving study early) · patients with schizophrenia

It is very uncertain whether BENZODIAZEPINES AS SOLE TREATMENT changes leaving the study early due to any reason (overall acceptability of… compared with PLACEBO (very low certainty).

1 finding from 1 review

Early warning signs training and treatment as usual vs treatment

Clinical response: mental state ‐ relapse ‐ medium term Relapse rate · patients with schizophrenia

It is very uncertain whether early warning signs training and treatment as usual changes relapse: Rate of relapse compared with treatment (very low certainty).

1 finding from 1 review

Early warning signs training and treatment as usual vs treatment

Service use: Time to re‐hospitalisation · patients with schizophrenia

It is very uncertain whether early warning signs training and treatment as usual changes service use: Time to re‐hospitalisation compared with treatment (very low certainty).

1 finding from 1 review

Non‐integrated models of care ‐ Assertive community treatment only/Intensive case management/Specialised case management services vs usual care

Lost to treatment · people with both severe mental illness and substance misuse

It is very uncertain whether non‐integrated models of care ‐ Assertive community treatment… changes leaving the study early: Lost to treatment compared with standard care (very low certainty).

1 finding from 1 review

Specialised early intervention (SEI) vs treatment

Recovered · recent‐onset psychosis (less than three years since the start of psychotic symptoms and either first or second psychotic episode)

Specialised early intervention (SEI) may leads to higher global state: recovery (assessed by proportion recovered, as defined… compared with treatment (low certainty).

1 finding from 1 review

Specialised early intervention (SEI) vs treatment

Service use: disengagement from services (assessed by proportion disengaged, as defined by the study, at end of treatment) · recent‐onset psychosis (less than three years since the start of psychotic symptoms and either first or second psychotic episode)

Specialised early intervention (SEI) probably leads to lower service use: disengagement from services (assessed by proportion… compared with treatment (moderate certainty).

1 finding from 1 review

Specialised early intervention (SEI) vs treatment

Service use: admission to psychiatric hospital (assessed by proportion admitted at end of treatment) · recent‐onset psychosis (less than three years since the start of psychotic symptoms and either first or second psychotic episode)

Specialised early intervention (SEI) showed no clear difference in service use: admission to psychiatric hospital (assessed by… compared with treatment (low certainty).

1 finding from 1 review

Specialised early intervention (SEI) vs treatment

Mental state: 1b.Average end point score on various outcomes‐PANSS (medium‐term) ‐ Medium term ‐ PANSS general psychopathology end point score (low = favourable) · recent‐onset psychosis (less than three years since the start of psychotic symptoms and either first or second psychotic episode)
1 finding from 1 review

Specialised early intervention (SEI) vs treatment

Death: all‐cause mortality (assessed by proportion deceased at end of treatment) · recent‐onset psychosis (less than three years since the start of psychotic symptoms and either first or second psychotic episode)

Specialised early intervention (SEI) showed no clear difference in death: all‐cause mortality (assessed by proportion deceased at end… compared with treatment (low certainty).

1 finding from 1 review