Cochrane · systematic review · CD013288
Specialised early intervention teams for recent‐onset psychosis
Puntis, S, Minichino, A, De Crescenzo, F, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
SchizophreniaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 14.3%Low 5 · 71.4%Moderate 1 · 14.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Specialised early intervention (SEI) compared to treatment as usual (TAU) for recent‐onset psychosis at end of treatment
Population: recent‐onset psychosis (less than three years since the start of psychotic symptoms and either first or second psychotic episode)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Global state: recovery (assessed by proportion recovered, as defined by the study, at end of treatment) Specialised early intervention (SEI) vs treatment | RR 1.41 [1.01, 1.97] | 2 studies · 194 participants | Low Downgraded: imprecision, indirectness |
Service use: disengagement from services (assessed by proportion disengaged, as defined by the study, at end of treatment) Specialised early intervention (SEI) vs treatment | RR 0.5 [0.31, 0.79] | 3 studies · 630 participants | Moderate Downgraded: imprecision |
Service use: admission to psychiatric hospital (assessed by proportion admitted at end of treatment) Specialised early intervention (SEI) vs treatment | RR 0.91 [0.82, 1] | 4 studies · 1145 participants | Low Downgraded: imprecision |
Service use: number of days in psychiatric hospital (assessed by mean number of days in hospital at end of treatment) Specialised early intervention (SEI) vs treatment | no estimate extracted | 1 study · 547 participants | Low Downgraded: imprecision |
Mental state: average endpoint score on a general mental state scale (general psychopathology, assessed by PANNS at end of treatment)g Specialised early intervention (SEI) vs treatment | no estimate extracted | 2 studies · 304 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Death: all‐cause mortality (assessed by proportion deceased at end of treatment) Specialised early intervention (SEI) vs treatment | RR 0.21 [0.04, 1.2] | 3 studies · 741 participants | Low Downgraded: imprecision |
Functioning: average endpoint score on general functioning scale (global functioning, assessed by questionnaire at end of treatment) Specialised early intervention (SEI) vs treatment | no estimate extracted | 2 studies · 467 participants | Low Downgraded: risk of bias, indirectness |