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Evidence found and GRADE certainty

43 questions · 44 findings · 7 reviews · Schizophrenia

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No studies found 6 · 13.6%GRADE not reported 4 · 9.1%Very low 15 · 34.1%Low 14 · 31.8%Moderate 4 · 9.1%High 1 · 2.3%

Haloperidol discontinuation vs haloperidol continuation

Global state: 2. Clinically important change (no improvement) ‐ long term · schizophrenia

It is very uncertain whether haloperidol discontinuation changes global state: clinically important change ‒ not improved (CGI) compared with haloperidol continuation (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Continuation vs reduction of polypharmacy

Hospital readmission · patients with schizophrenia

It is very uncertain whether summary of findings table ‐ Continuation changes service use – readmission to hospital – total compared with reduction of polypharmacy (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Continuation vs reduction of polypharmacy

Adverse effects – leaving the study early due to adverse effects – overall tolerability – total · patients with schizophrenia

It is very uncertain whether summary of findings table ‐ Continuation changes adverse effects – leaving the study early due to adverse effects –… compared with reduction of polypharmacy (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Continuation vs reduction of polypharmacy

Leaving the study early ‐ for any reason ‐ overall acceptability (combined time points) · patients with schizophrenia

Summary of findings table ‐ Continuation may leads to lower leaving the study early due to any reason – overall acceptability… compared with reduction of polypharmacy (low certainty).

1 finding from 1 review

Summary of findings table ‐ Continuation vs reduction of polypharmacy

Adverse effects: ≥ 1 adverse effect – total · patients with schizophrenia

It is very uncertain whether summary of findings table ‐ Continuation changes adverse effects: ≥ 1 adverse effect – total compared with reduction of polypharmacy (very low certainty).

1 finding from 1 review

Combinations of antipsychotic drugs vs single antipsychotic drugs

Adverse events: Serious event or requiring discontinuation · schizophrenia or related disorders

It is very uncertain whether combinations of antipsychotic drugs changes adverse events: Serious event or requiring discontinuation compared with single antipsychotic drugs (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Antipsychotic dose reduction vs dose continuation

Hospital readmission · patients with schizophrenia

It is very uncertain whether summary of findings table ‐ Antipsychotic dose reduction changes service use ‐ readmission to hospital (combined time points) compared with dose continuation (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Antipsychotic dose reduction vs dose continuation

Withdrawals due to adverse events · patients with schizophrenia

Summary of findings table ‐ Antipsychotic dose reduction probably leads to higher adverse effect ‐ leaving the study early due to adverse effects ‐… compared with dose continuation (moderate certainty).

1 finding from 1 review