Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

471 questions · 478 findings · 111 reviews

No studies found 68 · 14.2%GRADE not reported 42 · 8.8%Very low 143 · 29.9%Low 133 · 27.8%Moderate 73 · 15.3%High 19 · 4%

Continuation vs discontinuation of antiplatelet therapy

Mortality within the longest · adults undergoing non‐cardiac surgery

Continuation showed no clear difference in all‐cause mortality (at longest compared with discontinuation of antiplatelet therapy (low certainty).

1 finding from 1 review

Continuation vs discontinuation of antiplatelet therapy

All‐cause mortality (up to 30 days) · adults undergoing non‐cardiac surgery

Continuation showed no clear difference in all‐cause mortality (up to 30 days) compared with discontinuation of antiplatelet therapy (low certainty).

1 finding from 1 review

Continuation vs discontinuation of antiplatelet therapy

Blood loss requiring transfusion of blood products (intraoperatively and postoperatively) · adults undergoing non‐cardiac surgery

Continuation showed no clear difference in blood loss requiring transfusion of blood products (intraoperatively… compared with discontinuation of antiplatelet therapy (moderate certainty).

1 finding from 1 review

Continuation vs discontinuation of antiplatelet therapy

Blood loss requiring further surgery (intraoperatively and postoperatively) · adults undergoing non‐cardiac surgery

Continuation showed no clear difference in blood loss requiring further surgery (intraoperatively and… compared with discontinuation of antiplatelet therapy (low certainty).

1 finding from 1 review

Continuation vs discontinuation of antiplatelet therapy

Ischaemic events: peripheral thrombosis, cerebral myocardial infarction (within 30 days of surgery) · adults undergoing non‐cardiac surgery

Continuation showed no clear difference in ischaemic events: peripheral thrombosis, cerebral myocardial… compared with discontinuation of antiplatelet therapy (low certainty).

1 finding from 1 review

Discontinuation vs continuation of antipsychotic medication

Success of withdrawal from antipsychotics · older people with dementia who had been taking an antipsychotic drug for at least 3 months

Discontinuation may leads to lower success of withdrawal from antipsychotics compared with continuation of antipsychotic medication (low certainty).

1 finding from 1 review

Abrupt discontinuation vs continuation of long‐term antidepressants

Relapse · participants with depressive or anxiety disorders

It is very uncertain whether abrupt discontinuation changes relapse (as defined by study authors) (HR) compared with continuation of long‐term antidepressants (very low certainty).

1 finding from 1 review

Abrupt discontinuation vs continuation of long‐term antidepressants

Adverse events · participants with depressive or anxiety disorders

It is very uncertain whether abrupt discontinuation changes adverse events compared with continuation of long‐term antidepressants (very low certainty).

1 finding from 1 review