Cochrane · systematic review · CD007726
Withdrawal versus continuation of long‐term antipsychotic drug use for behavioural and psychological symptoms in older people with dementia
Van Leeuwen, E, Petrovic, M, van Driel, ML, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Dementia and Cognitive ImprovementAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 28.6%Low 5 · 71.4%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Discontinuation compared to continuation of antipsychotic medication for behavioural and psychological symptoms in older people with dementia
Population: older people with dementia who had been taking an antipsychotic drug for at least 3 months
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Success of withdrawal from antipsychotics Discontinuation vs continuation of antipsychotic medication | no estimate extracted | 9 studies · 575 participants | Low Downgraded: indirectness |
Behavioural and psychological symptoms Discontinuation vs continuation of antipsychotic medication | no estimate extracted | 7 studies · 519 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Adverse events Discontinuation vs continuation of antipsychotic medication | no estimate extracted | 5 studies · 381 participants | Low Downgraded: indirectness |
Quality of life (QoL) Discontinuation vs continuation of antipsychotic medication | no estimate extracted | 2 studies · 119 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Cognitive function Discontinuation vs continuation of antipsychotic medication | no estimate extracted | 5 studies · 365 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Use of physical restraint Discontinuation vs continuation of antipsychotic medication | no estimate extracted | 1 study · 36 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Mortality Discontinuation vs continuation of antipsychotic medication | no estimate extracted | 2 studies · 275 participants | Very low Downgraded: risk of bias, imprecision, indirectness |