Summary of findings table ‐ Continuation vs reduction of polypharmacy: Adverse effects – leaving the study early due to adverse effects – overall tolerability – total
- Population
- patients with schizophrenia
- Intervention
- Summary of findings table ‐ Continuation
- Comparison
- reduction of polypharmacy
- Outcome
- Adverse effects – leaving the study early due to adverse effects – overall tolerability – total
It is very uncertain whether summary of findings table ‐ Continuation changes adverse effects – leaving the study early due to adverse effects –… compared with reduction of polypharmacy (very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Summary of findings table ‐ Continuation vs reduction of polypharmacy Adverse effects – leaving the study early due to adverse effects – overall tolerability – total · people with schizophrenia It is very uncertain whether summary of findings table ‐ Continuation changes adverse effects – leaving the study early due to adverse effects –… compared with reduction of polypharmacy (very low certainty). Antipsychotic polypharmacy reduction versus polypharmacy continuation for people with schizophrenia (2022) · Cochrane Headline outcomes only | RR 4.37 [0.77, 24.88] | 3 studies · 176 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Antipsychotic polypharmacy reduction versus polypharmacy continuation for people with schizophrenia 2022 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.