Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

37 questions · 38 findings · 13 reviews · Schizophrenia · Headline outcomes only

No studies found 1 · 2.6%GRADE not reported 3 · 7.9%Very low 17 · 44.7%Low 11 · 28.9%Moderate 6 · 15.8%High 0 · 0%

Structured risk assessment vs usual care

Use of coercive measure: use of seclusion room (participants) · aggressive behaviour in schizophrenia

Structured risk assessment showed no clear difference in use of coercive measure: use of seclusion room (participants) compared with standard professional care (low certainty).

1 finding from 1 review

Extended specialised early intervention (SEI) teams vs standard SEI teams plus treatment

Service use: disengagement from services(assessment varied) · recent‐onset psychosis

Extended specialised early intervention (SEI) teams may leads to lower service use: disengagement from services(assessment varied) compared with standard SEI teams plus treatment (low certainty).

1 finding from 1 review

Group B cognitive behavioural therapy: cognitive behavioural therapy + risperidone vs placebo and cognitive and behavioural therapies

Adverse effects: specific ‐ doctors' assessment of adverse effects UKU (events) Medium‐term · people in the prodromal stage of psychosis

It is very uncertain whether group B cognitive behavioural therapy: cognitive behavioural therapy… changes adverse effects: specific ‐ doctors' assessment of adverse effects… compared with cognitive behavioural therapy + placebo (very low certainty).

1 finding from 1 review

Group C cognitive behavioural therapy: cognitive behavioural therapy + placebo vs placebo or supportive treatment

Adverse effects: specific ‐ doctors' assessment of adverse effects UKU (events) Medium‐term · people in the prodromal stage of psychosis

It is very uncertain whether group C cognitive behavioural therapy: cognitive behavioural therapy… changes adverse effects: specific ‐ doctors' assessment of adverse effects… compared with supportive therapy + placebo (very low certainty).

1 finding from 1 review

Group C cognitive behavioural therapy: cognitive behavioural therapy + risperidone vs placebo or supportive treatment

Adverse effects: specific ‐ doctors' assessment of adverse effects UKU (events) Medium‐term · people in the prodromal stage of psychosis

It is very uncertain whether group C cognitive behavioural therapy: cognitive behavioural therapy… changes adverse effects: doctors' assessment of adverse effects UKU (events)… compared with supportive therapy + placebo (very low certainty).

1 finding from 1 review

SULPIRIDE vs placebo

Safety assessments ‐ medium term ‐ not measured · patients with schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

ANY INTERMITTENT DRUG TECHNIQUE vs MAINTENANCE THERAPY

Global state: average score: long term (+ 26 weeks) Global Assessment Scale (GAS). Scale from: 0 to 100. · patients with schizophrenia
2 findings from 1 review