Death at hospital discharge · neonates with clinical and microbiological features of bacterial meningitis
It is very uncertain whether adjunctive steroid changes all‐cause death until hospital discharge compared with placebo (very low certainty).
1 finding from 1 review
Developmental delay at ≥ 18 months · neonates with clinical and microbiological features of bacterial meningitis
Adjunctive steroid showed no clear difference in number of participants with developmental delay compared with placebo (low certainty).
1 finding from 1 review
Hearing loss · neonates with clinical and microbiological features of bacterial meningitis
Adjunctive steroid showed no clear difference in hearing loss at 2 years of age compared with placebo (low certainty).
2 findings from 1 review
Number and nature of adverse events secondary to corticosteroid use (hospital‐acquired infection) · individuals with influenza
It is very uncertain whether corticosteroid therapy changes number and nature of adverse events secondary to corticosteroid use… compared with no corticosteroid therapy (very low certainty).
1 finding from 1 review
Death at 1 month (adults) · patients with Pneumocystis jiroveci pneumonia and HIV infection
Adjunctive corticosteroids leads to lower death at 1 month (adults) compared with no such treatment (high certainty).
1 finding from 1 review
Death at 3 to 4 months (adults) · patients with Pneumocystis jiroveci pneumonia and HIV infection
Adjunctive corticosteroids leads to lower death at 3 to 4 months (adults) compared with no such treatment (high certainty).
1 finding from 1 review
Death in hospital; children · patients with Pneumocystis jiroveci pneumonia and HIV infection
Adjunctive corticosteroids showed no clear difference in death in hospital; children compared with no such treatment (moderate certainty).
1 finding from 1 review
Need for mechanical ventilation · patients with Pneumocystis jiroveci pneumonia and HIV infection
Adjunctive corticosteroids probably leads to lower need for mechanical ventilation at 1 month compared with no such treatment (moderate certainty).
1 finding from 1 review
Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
Intralesional steroid injection plus adjunctive treatment showed no clear difference in maximal mouth opening (interincisal distance) compared with intralesional steroid injection alone (low certainty).
2 findings from 1 review
All‐cause mortality Up to 28 days following admission · individuals with influenza
It is very uncertain whether corticosteroid therapy changes number of deaths at 30 days following admission (30‐day mortality)a compared with no corticosteroid therapy (very low certainty).
1 finding from 1 review
Incidence of admissions to the ICU · individuals with influenza
It is very uncertain whether corticosteroid therapy changes rate of admission to intensive care units compared with no corticosteroid therapy (very low certainty).
1 finding from 1 review
Incidence of mechanical ventilation · individuals with influenza
It is very uncertain whether corticosteroid therapy changes proportion of participants requiring mechanical ventilation compared with no corticosteroid therapy (very low certainty).
1 finding from 1 review
Outcomes* · eyes with acute endophthalmitis following an intraocular procedure (e.g. surgery, intravitreous injection)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Complete resolution of endophthalmitis at 3 months' · eyes with acute endophthalmitis following an intraocular procedure (e.g. surgery, intravitreous injection)
It is very uncertain whether combined steroid and antibiotic therapy changes complete resolution of endophthalmitis at 3 months' compared with antibiotics alone (very low certainty).
1 finding from 1 review
Visual acuity · eyes with acute endophthalmitis following an intraocular procedure (e.g. surgery, intravitreous injection)
Combined steroid and antibiotic therapy may leads to higher visual acuity 6/6 to 6/18 at 3 months' compared with antibiotics alone (low certainty).
2 findings from 1 review
Improvement in visual acuity at 3 months' · eyes with acute endophthalmitis following an intraocular procedure (e.g. surgery, intravitreous injection)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intraocular pressure ( · eyes with acute endophthalmitis following an intraocular procedure (e.g. surgery, intravitreous injection)
1 finding from 1 review
Adverse events at 3 to 12 months' · eyes with acute endophthalmitis following an intraocular procedure (e.g. surgery, intravitreous injection)
Combined steroid and antibiotic therapy showed no clear difference in adverse events at 3 to 12 months' compared with antibiotics alone (low certainty).
1 finding from 1 review
Costs · eyes with acute endophthalmitis following an intraocular procedure (e.g. surgery, intravitreous injection)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Reduction in pain · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment
1 finding from 1 review