Cochrane · systematic review · CD010435
Adjuvant corticosteroids for reducing death in neonatal bacterial meningitis
Ogunlesi, TA, Odigwe, CC, Oladapo, OT · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
4
current version
GRADE rated
4
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 25%Low 3 · 75%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Adjunctive steroid versus placebo for reducing death in neonatal bacterial meningitis
Population: neonates with clinical and microbiological features of bacterial meningitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause death until hospital discharge Adjunctive steroid vs placebo | RR 0.46 [0.24, 0.88] | 2 studies · 132 participants | Very low |
Number of participants with developmental delay Adjunctive steroid vs placebo | RR 0.77 [0.32, 1.87] | 1 study · 38 participants | Low |
Hearing loss at 2 years of age Adjunctive steroid vs placebo | RR 1.8 [0.18, 18.21] | 1 study · 38 participants | Low |
Hearing loss at 4 to 10 weeks after discharge Adjunctive steroid vs placebo | RR 0.41 [0.17, 0.98] | 1 study · 59 participants | Low Downgraded: imprecision, inconsistency |