Cochrane · systematic review · CD010406
Corticosteroids as adjunctive therapy in the treatment of influenza
Lansbury, L, Rodrigo, C, Leonardi‐Bee, J, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
4
current version
GRADE rated
4
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 4 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 2 versionsCorticosteroid therapy compared to no corticosteroid therapy in the treatment of influenza
Population: individuals with influenza
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of deaths at 30 days following admission (30‐day mortality)a Corticosteroid therapy vs no corticosteroid therapy | OR 3.9 [2.31, 6.6] | 21 studies · 9536 participants | Very low Downgraded: risk of bias, inconsistency |
Rate of admission to intensive care units Corticosteroid therapy vs no corticosteroid therapy | OR 5.13 [4.26, 6.17] | 1 study · 2141 participants | Very low Downgraded: risk of bias |
Number and nature of adverse events secondary to corticosteroid use (hospital‐acquired infection) Corticosteroid therapy vs no corticosteroid therapy | OR 2.74 [1.51, 4.95] | 7 studies · 6114 participants | Very low Downgraded: risk of bias, inconsistency |
Proportion of participants requiring mechanical ventilation Corticosteroid therapy vs no corticosteroid therapy | no estimate extracted | 4 studies · 4364 participants | Very low Downgraded: risk of bias, inconsistency |