Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,454 questions · 3,562 findings · 816 reviews · Headline outcomes only

No studies found 538 · 15.1%GRADE not reported 239 · 6.7%Very low 933 · 26.2%Low 1,041 · 29.2%Moderate 612 · 17.2%High 199 · 5.6%

Surgical portosystemic shunts vs transjugular intrahepatic portosystemic shunt (TIPS)

All‐cause mortality at 30 days · people with cirrhotic portal hypertension

It is very uncertain whether surgical portosystemic shunts changes all‐cause mortality at 30 days compared with transjugular intrahepatic portosystemic shunt (TIPS) (very low certainty).

1 finding from 1 review

Surgical portosystemic shunts vs transjugular intrahepatic portosystemic shunt (TIPS)

Number of participants with Variceal rebleeding episodes at 30 days · people with cirrhotic portal hypertension

It is very uncertain whether surgical portosystemic shunts changes number of participants with Variceal rebleeding episodes at 30 days compared with transjugular intrahepatic portosystemic shunt (TIPS) (very low certainty).

1 finding from 1 review

Laparoscopic vs open appendectomy

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · patients with suspected appendicitis
3 findings from 1 review

Preoperative radiotherapy vs surgery

Postoperative morbidity ‐ sepsis (within 30 days after surgery) · People with localised rectal carcinoma

Preoperative radiotherapy may leads to higher postoperative morbidity ‐ sepsis (within 30 days after surgery) compared with surgery alone (low certainty).

1 finding from 1 review

Preoperative radiotherapy vs surgery

Postoperative morbidity ‐ surgical complications (within 30 days after surgery) · People with localised rectal carcinoma

Preoperative radiotherapy may leads to higher postoperative morbidity ‐ surgical complications (within 30 days… compared with surgery alone (low certainty).

1 finding from 1 review

Macrolides vs doxycycline

Resolution of fever within 5 days · adults and adolescents with scrub typhus

Macrolides showed no clear difference in resolution of fever within 5 days compared with doxycycline (low certainty).

1 finding from 1 review

Antibiotics vs placebo or usual care

Serious adverse events Duration 3 days to 3 weeks · acute asthma exacerbation

Antibiotics showed no clear difference in serious adverse events Duration 3 days to 3 weeks compared with placebo or usual care (low certainty).

1 finding from 1 review

Intervention not reported

Limb salvage at 30 days · patients seeking treatment for initial management of acute limb ischaemia

The intervention showed no clear difference in limb salvage at 30 days (low certainty).

1 finding from 1 review

Intervention not reported

Amputation at 30 days · patients seeking treatment for initial management of acute limb ischaemia

The intervention showed no clear difference in amputation at 30 days (low certainty).

1 finding from 1 review

Intervention not reported

Death at 30 days · patients seeking treatment for initial management of acute limb ischaemia

The intervention showed no clear difference in death at 30 days (moderate certainty).

1 finding from 1 review