Cochrane · systematic review · CD002784
Surgery versus thrombolysis for initial management of acute limb ischaemia
Darwood, R, Berridge, DC, Kessel, DO, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
VascularAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 28.6%Low 4 · 57.1%Moderate 1 · 14.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Is surgery or thrombolysis more effective for initial management of acute limb ischaemia?
Population: patients seeking treatment for initial management of acute limb ischaemia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Limb salvage at 30 days | OR 1.02 [0.41, 2.55] | 4 studies · 636 participants | Low Downgraded: risk of bias, inconsistency |
Amputation at 30 days | OR 0.97 [0.51, 1.85] | 3 studies · 616 participants | Low Downgraded: risk of bias, inconsistency |
Death at 30 days | OR 0.59 [0.31, 1.14] | 4 studies · 636 participants | Moderate Downgraded: risk of bias |
Vessel patency at 30 days | OR 0.46 [0.08, 2.76] | 1 study · 20 participants | Very low Downgraded: risk of bias, imprecision |
Major haemorrhage at 30 days | OR 3.22 [1.79, 5.78] | 4 studies · 1070 participants | Low Downgraded: risk of bias, imprecision |
Stroke at 30 days | OR 5.33 [0.95, 30.11] | 5 studies · 1180 participants | Low Downgraded: risk of bias, imprecision |
Distal embolisation at 30 days | OR 31.68 [6.23, 161.07] | 3 studies · 678 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |