Cochrane · systematic review · CD002150
Antibiotics for treating scrub typhus
El Sayed, I, Liu, Q, Wee, I, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Infectious DiseasesAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
15
current version
GRADE rated
11
No studies
4
Included studies
NR
No studies 4 · 26.7%Ungraded 0 · 0%Very low 8 · 53.3%Low 3 · 20%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Doxycycline compared to tetracycline for treating scrub typhus
Population: adults with scrub typhus
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Treatment failure Doxycycline vs tetracycline | RR 6.85 [0.38, 124.38] | 1 study · 116 participants | Very low Downgraded: risk of bias, imprecision |
Resolution of fever within 48 hours Doxycycline vs tetracycline | RR 1.14 [0.9, 1.44] | 1 study · 55 participants | Low Downgraded: risk of bias, imprecision |
Resolution of fever within 5 days Doxycycline vs tetracycline | no estimate extracted | NR | No studies |
Time to defervescence Doxycycline vs tetracycline | no estimate extracted | 1 study · 116 participants | Low Downgraded: risk of bias, imprecision |
Serious adverse events Doxycycline vs tetracycline | no estimate extracted | NR | No studies |
Macrolides compared to doxycycline for treating scrub typhus
Population: adults and adolescents with scrub typhus
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Treatment failure Macrolides vs doxycycline | RR 2.71 [0.12, 63.84] | 3 studies · 242 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Resolution of fever within 48 hours Macrolides vs doxycycline | RR 0.81 [0.32, 2.03] | 2 studies · 150 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Resolution of fever within 5 days Macrolides vs doxycycline | RR 1.05 [0.99, 1.1] | 2 studies · 185 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Time to defervescence Macrolides vs doxycycline | no estimate extracted | 3 studies · 242 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Serious adverse events Macrolides vs doxycycline | no estimate extracted | 3 studies · 242 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Rifampicin compared to doxycycline for treating scrub typhus
Population: adults with scrub typhus
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Treatment failure Rifampicin vs doxycycline | no estimate extracted | 1 study · 78 participants | Very low Downgraded: risk of bias, imprecision |
Resolution of fever within 48 hours Rifampicin vs doxycycline | RR 1.68 [1.1, 2.57] | 1 study · 78 participants | Very low Downgraded: risk of bias, imprecision |
Resolution of fever within 5 days Rifampicin vs doxycycline | no estimate extracted | NR | No studies |
Time to defervescence Rifampicin vs doxycycline | no estimate extracted | 1 study · 78 participants | Very low Downgraded: risk of bias, imprecision |
Serious adverse events Rifampicin vs doxycycline | no estimate extracted | NR | No studies |