Lumbar spine bone mineral density (BMD) · European GWAS participants
The SVMR IVW interval excluded zero.
1 finding from 1 review
Osteoporosis · European GWAS participants
The SVMR Weighted Median interval excluded the null.
3 findings from 1 review
OR 1.260 [1.017, 1.560]
483725 participants
GRADE not reported
OR 1.162 [0.998, 1.353]
483725 participants
GRADE not reported
OR 1.329 [0.991, 1.782]
483725 participants
GRADE not reported
Lumbar spine and pelvis fracture · European GWAS participants
The MVMR MR-Egger interval included the null.
1 finding from 1 review
OR 1.034 [0.769, 1.390]
490700 participants
GRADE not reported
Postmenopausal osteoporosis with pathological fracture · European GWAS participants
The MVMR MR-Egger interval included the null.
1 finding from 1 review
OR 1.281 [0.640, 2.565]
281786 participants
GRADE not reported
Lumbar spine bone mineral density (BMD) · European GWAS participants
The MVMR IVW interval excluded zero.
1 finding from 1 review
Forearm fracture · European GWAS participants
The SVMR Weighted Median interval included the null.
3 findings from 1 review
OR 0.914 [0.799, 1.046]
490889 participants
GRADE not reported
OR 0.883 [0.738, 1.057]
490889 participants
GRADE not reported
OR 0.920 [0.836, 1.011]
490889 participants
GRADE not reported
Osteoporosis with pathological fracture · European GWAS participants
The MVMR MR-Egger interval included the null.
1 finding from 1 review
OR 1.011 [0.876, 1.167]
376746 participants
GRADE not reported
Caries (DMFT) and enamel defects · Preterm children (about 8 years old) in the United Arab Emirates (Dubai)
One study found preterm children had higher DMFT and a fourfold higher prevalence of enamel defects than full-term children (narrative synthesis; not GRADE-rated).
1 finding from 1 review
Alshehhi et al. (Dubai) reported a significantly higher mean DMFT (1.00 vs 0.38) and a 4-times higher prevalence of enamel defects (58.15% vs 24.2%; OR 4.33, 95% CI 2.01-9.36) in preterm vs full-term children, highest…
1 study
GRADE not reported
Osteoporosis with pathological fracture · European-ancestry adults
In multivariable MR, genetically predicted dental caries (DMFS) had no significant causal effect on osteoporosis with pathological fracture (OR 1.279, not significant).
2 findings from 1 review
Osteoporosis · European-ancestry adults
In multivariable MR (adjusted for periodontitis), higher genetically predicted dental caries (DMFS) causally increased osteoporosis risk (OR 1.165, moderate evidence).
2 findings from 1 review
Bone mineral density in forearm · European-ancestry adults
Genetically predicted dental caries (DMFS) had no causal effect on forearm BMD.
1 finding from 1 review
Lumbar spine and pelvis fracture · European-ancestry adults
Genetically predicted dental caries (DMFS) had no significant causal effect on fracture of lumbar spine and pelvis (multivariable MR, OR 0.968).
2 findings from 1 review
Forearm fracture · European-ancestry adults
Genetically predicted dental caries (DMFS) had no significant causal effect on fracture of forearm (multivariable MR, OR 0.973).
2 findings from 1 review
Postmenopausal osteoporosis with pathological fracture · Postmenopausal women (European ancestry)
In multivariable MR (adjusted for periodontitis), genetically predicted dental caries (DMFS) causally increased postmenopausal osteoporosis with pathological fracture (OR 1.422, moderate evidence).
2 findings from 1 review
Femoral neck bone mineral density (FN-BMD) · European-ancestry adults
Genetically predicted dental caries (DMFS) had no causal effect on femoral neck BMD.
1 finding from 1 review
Femur fracture · European-ancestry adults
Genetically predicted dental caries (DMFS) had no significant causal effect on fracture of femur (multivariable MR, OR 1.069).
2 findings from 1 review
Antibody titres to periodontal pathogens · Adults with periodontitis
In one case-control study, depression as a marker of social isolation was associated with elevated antibody titres to periodontal pathogens at baseline and 1-year follow-up; not pooled (ungraded).
1 finding from 1 review
Oral health-related quality of life · people aged 60 years and older living in the community
OHRQoL did not differ significantly by country-level edentulism prevalence; no pooled estimate was reported in the text (ungraded).
1 finding from 1 review
Oral health-related quality of life · people aged 60 years and older living in the community
Lower country-level dental caries prevalence was associated with better OHRQoL (low-prevalence pooled mean 81.5, 95% CI 76.5 to 86.6, higher than high-prevalence countries); statistically significant (ungraded).
1 finding from 1 review
MEAN 81.5 [76.5, 86.6]
Studies not reported
GRADE not reported
Dental caries - genome-wide-significant loci · Japanese adults (present-study cohort: 30,859 dental caries cases / 14,666 controls)
The present Japanese GWAS found no genome-wide-significant loci for dental caries (top suggestive rs140784657); ungraded.
1 finding from 1 review
Genome-wide association meta-analysis identifies two novel loci associated with dental caries. 2024 All outcomesLifelong (germline genotype) · Population-based genetic association study (Japanese direct-to-consumer genetic testing cohort) · Present-study GWAS (Japanese)
In the present Japanese GWAS, no loci reached genome-wide significance (P<5E-8) for dental caries; several loci reached the suggestive level (P<1E-5). Top-associated variant rs140784657 (intergenic). All 47 lead…
1 study · 45525 participants
GRADE not reported