Depression and social isolation (psychosocial strain) vs No depression or lower psychosocial strain: Antibody titres to periodontal pathogens
In one case-control study, depression as a marker of social isolation was associated with elevated antibody titres to periodontal pathogens at baseline and 1-year follow-up; not pooled (ungraded).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Depression and social isolation (psychosocial strain) vs No depression or lower psychosocial strain Antibody titres to periodontal pathogens · Adults with periodontitis · Baseline and 1-year follow-up, Community adults, USA (Erie County Risk Factor Study) In one case-control study, depression as a marker of social isolation was associated with elevated antibody titres to periodontal pathogens at baseline and 1-year follow-up; not pooled (ungraded). Social-Biological Interactions in Oral Disease: A 'Cells to Society' View. (2016) All outcomes | no estimate extracted | 1 study · 148 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Social-Biological Interactions in Oral Disease: A 'Cells to Society' View. 2016 All outcomes | Not specified; literature search covered publications from 1994 to 2015 | 10 | Not applicable |
Studies behind the findings
The primary studies the full-text reviews tie to this outcome. Reviews with headline outcomes only do not list them here.
- Moss et al. 1996 · included by 1 of these review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.