Genetically predicted DMFS (dental caries) vs Reference (1-SD lower genetically predicted DMFS): Postmenopausal osteoporosis with pathological fracture
- Population
- Postmenopausal women (European ancestry)
- Intervention
- Genetically predicted DMFS (dental caries)
- Comparison
- Reference (1-SD lower genetically predicted DMFS)
- Outcome
- Postmenopausal osteoporosis with pathological fracture
In multivariable MR (adjusted for periodontitis), genetically predicted dental caries (DMFS) causally increased postmenopausal osteoporosis with pathological fracture (OR 1.422, moderate evidence).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Genetically predicted dental caries (DMFS index) vs Reference (1-SD lower genetically predicted DMFS) Postmenopausal osteoporosis with pathological fracture · Postmenopausal women (European ancestry) · Lifelong genetic liability, European-ancestry population (two-sample MR: GLIDE exposures; FinnGen osteoporosis/fractures; GeFOS BMD), MVMR (IVW), adjusted for periodontitis In multivariable MR (adjusted for periodontitis), genetically predicted dental caries (DMFS) causally increased postmenopausal osteoporosis with pathological fracture (OR 1.422, moderate evidence). From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) All outcomes | OR 1.422 [1.027, 1.969] | 281786 participants | GRADE not reported |
Genetically predicted dental caries (DMFS index) vs Reference (1-SD lower genetically predicted DMFS) Postmenopausal osteoporosis with pathological fracture · Postmenopausal women (European ancestry) · Lifelong genetic liability, European-ancestry population (two-sample MR: GLIDE exposures; FinnGen osteoporosis/fractures; GeFOS BMD), SVMR (IVW), total causal effect In single-variable MR, genetically predicted dental caries (DMFS) had no significant causal effect on postmenopausal osteoporosis with pathological fracture (OR 1.343, not significant). From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. (2025) All outcomes | OR 1.343 [0.948, 1.901] | 281786 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes | Not applicable (secondary analysis of published GWAS summary statistics) | 3 | Not applicable |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS · European GWAS participants · 1 review
- Genetically predicted DMFS (dental caries) vs Lower genetically predicted DMFS, adjusted for periodontitis · European GWAS participants · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.