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Evidence found and GRADE certainty

2,745 questions · 4,389 findings · 203 reviews · Oral Health

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No studies found 39 · 0.9%GRADE not reported 3,844 · 87.6%Very low 198 · 4.5%Low 137 · 3.1%Moderate 134 · 3.1%High 37 · 0.8%

17-24 remaining teeth vs 25-32 remaining teeth

Atherosclerotic cardiovascular disease (ACVD)-related events (morbidity and mortality) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies

In prospective cohorts, adults with 17-24 teeth had a higher cumulative incidence of ACVD-related events than adults with 25-32 teeth (RR 1.73, 95% CI 1.22 to 2.45; 4 cohort studies, I2=87%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).

1 finding from 1 review

0-19 remaining teeth vs 20-32 remaining teeth

All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies

In prospective cohorts, the crude HR for all-cause mortality in adults with 0-19 teeth vs adults with 20-32 teeth was 2.47 (95% CI 2.40 to 2.54; 2 studies, I2=0%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).

4 findings from 1 review
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Digital bitewing radiography, phosphor plate (PSP) vs Histological validation of dental tissues (gold standard)

Diagnostic accuracy for proximal caries detection (caries detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro)

Under in vitro conditions, phosphor-plate digital bitewing radiography had a summary ROC AUC of 0.82 for proximal caries detection at the caries detection level; ungraded.

4 findings from 1 review
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Conventional bitewing radiography (E-speed film) vs Direct visual examination after tooth separation or bioptical cavity preparation

Diagnostic accuracy for proximal caries detection (dentin detection level) · Patients with permanent posterior teeth, proximal surfaces assessed clinically (in vivo)

Under in vivo conditions, conventional E-speed bitewing radiography had a pooled specificity of 0.91 (95% CI 0.80, 0.96) for proximal caries detection at the dentin detection level; ungraded.

4 findings from 1 review
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Coating material (bonding material or sealant) WITH fluoride release vs Coating material WITHOUT fluoride release

Initiation of white spot lesions (WSL), visual-tactile assessment · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)

Fluoride-releasing coating material did not show a statistically significant reduction in new white spot lesions versus non-fluoride coating (very low certainty).

1 finding from 1 review

Laser fluorescence (DIAGNOdent 2190/pen) vs Direct visual examination after tooth separation or bioptical cavity preparation

Diagnostic accuracy for proximal caries detection (caries detection level) · Patients with permanent posterior teeth, proximal surfaces assessed clinically (in vivo)

Under in vivo conditions, laser fluorescence (DIAGNOdent 2190) had a summary ROC AUC of 0.96 for proximal caries detection at the caries detection level; ungraded.

4 findings from 1 review
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Dental caries assessment (WHO/clinical diagnostic criteria; caries = DMFT>0) vs None (descriptive prevalence meta-analysis)

Dental caries prevalence · General Pakistani population (all ages and both sexes; predominantly children and adolescents)

In permanent dentition, the pooled prevalence of dental caries was 57.2% (95% CI 26.3 to 85.3); ungraded.

10 findings from 1 review
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Micro-invasive treatment (proximal sealing or resin infiltration): resin sealant, glass ionomer sealant, polyurethane/adhesive patch, or resin infiltration vs Non-invasive / control treatment

Radiographic proximal caries lesion progression · Patients with non-cavitated proximal (approximal) caries lesions (primary or permanent dentition)

In the low caries-risk subgroup, micro-invasive treatment reduced the odds of lesion progression (OR 0.24, 95% CI 0.08 to 0.72; ungraded subgroup).

9 findings from 1 review
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Fluoride concentration relative to the acceptable range (electrometric ion-selective electrode measurement; acceptable range mostly 0.6-0.8 ppmF) vs None (descriptive proportion meta-analysis)

Water samples with fluoride concentration below the acceptable range · Artificially fluoridated public water supply in Brazilian cities (water samples under external control)

In the Northeast Brazilian region, a pooled 79.7% of water samples had fluoride below the acceptable range; ungraded.

2 findings from 1 review

Fibre-optic transillumination (FOTI) vs Histological validation (serial sectioning, grinding, hemisection, or microradiography)

Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces

In in vitro, fibre-optic transillumination pooled specificity was 0.97 (95% CI 0.89 to 0.994) for occlusal caries at the dentin detection level; ungraded.

4 findings from 1 review
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Clear aligners (Invisalign / thermoformed aligners) vs Fixed appliances

Lactobacilli presence (CFU > 10^5) · Adults undergoing orthodontic treatment

Aligners probably lower the risk of high lactobacilli counts versus fixed appliances in adults at 3 months (RR 0.09, 95% CI 0.02 to 0.47; low certainty).

2 findings from 1 review

Molar-incisor hypomineralisation (MIH) assessment vs None (descriptive prevalence review; subgroup analyses by urban/rural status, country and year)

MIH prevalence · School-aged children in the United Arab Emirates (Dubai)

MIH prevalence among school-aged children in Dubai ranged from 7.6% to 27.2% across two studies, higher in females and low-socioeconomic-class schools (narrative synthesis; not GRADE-rated).

1 finding from 1 review

Clear aligners (Invisalign / thermoformed aligners) vs Fixed appliances

Average fluorescence loss (dF%) · Adults undergoing orthodontic treatment

A single study reported lower average fluorescence (mineral) loss with aligners versus fixed appliances in adults at 3 months (MD -1.40, 95% CI -2.15 to -0.65; ungraded).

1 finding from 1 review

Higher number of lost teeth (per one additional lost tooth) vs Fewer lost teeth (continuous, per-tooth increment)

All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies

Each additional lost tooth was associated with a multivariable-adjusted HR of 1.02 (95% CI 1.01 to 1.03) for all-cause mortality (11 studies, I2=89%), statistically significant; GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).

3 findings from 1 review

Conventional bitewing radiography (D-speed film) vs Histological validation of dental tissues (gold standard)

Diagnostic accuracy for proximal caries detection (caries detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro)

Under in vitro conditions, conventional D-speed bitewing radiography had a pooled diagnostic odds ratio of 5.2 (95% CI 1.6, 16.8) for proximal caries detection at the caries detection level; ungraded.

4 findings from 1 review
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