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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
5,762 questions in 263 reviews · Dental caries
current versionsNo studies 321 · 5.6%Ungraded 4,450 · 77.2%Very low 455 · 7.9%Low 297 · 5.2%Moderate 200 · 3.5%High 39 · 0.7%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Longitudinal follow-up over time (natural caries progression; no assigned intervention) vs Within-cohort change from baseline to follow-up (>=3 y) Annual increment in DMFS (permanent dentition) · Children and adolescents (permanent dentition, D3, up to 21 y), Western or comparable populations · Per year of follow-up, Baseline caries experience: moderate Caries Progression Rates Revisited: A Systematic Review. (2019) | 0.23 to 1.23 | 13 studies · 16473 participants | Ungraded |
Resin infiltration vs No treatment Arrest or reversal of noncavitated approximal carious lesions · Children and adults with noncavitated carious lesions on approximal surfaces (primary and permanent teeth) · 12-36 mo Nonrestorative Treatments for Caries: Systematic Review and Network Meta-analysis. (2019) | RR 2.11 [1.08, 4.13] | 6 studies · 565 participants | Low |
Longitudinal follow-up over time (natural caries progression; no assigned intervention) vs Within-cohort change from baseline to follow-up (>=3 y) Annual increment in DMFT (permanent dentition) · Children and adolescents (permanent dentition, D3, up to 21 y), Western or comparable populations · Per year of follow-up, Baseline caries experience: high Caries Progression Rates Revisited: A Systematic Review. (2019) | 0.39 | 1 study · 4380 participants | Ungraded |
Salvadora persica (miswak) mouthrinse vs Placebo rinse Post-intervention mean plaque score · Medically healthy individuals (adults and children, 6-60 years) · Post-intervention The antiplaque/anticariogenic efficacy of Salvadora persica (Miswak) mouthrinse in comparison to that of… (2019) | MD -0.59 [-0.82, -0.35] | 12 studies · 452 participants | Ungraded |
Dental cavity liner (e.g. calcium hydroxide, glass ionomer, resin-modified glass ionomer, or flowable composite) placed under the restoration vs No liner (resin-based composite bonded directly to the tooth) Cost of materials · Adults or children with a Class I or Class II resin-based composite restoration in a permanent posterior tooth Dental cavity liners for Class I and Class II resin‐based composite restorations (2019) · Cochrane | One study (Strober 2013) reported cost, concluding that eliminating a resin-modified glass ionomer lining could save approximately USD 4.50 per filling (about USD 2000 per dentist per year). No comparative effect… | 1 study | Ungraded |
Intervention NR Care index, primary teeth · Disability: autism Dental caries experience, care index and restorative index in children with learning disabilities and… (2019) | no estimate extracted | 2 studies | Ungraded |
Resin infiltration + 5% NaF varnish vs No treatment Arrest or reversal of noncavitated occlusal carious lesions · Children and adults with noncavitated carious lesions on occlusal surfaces (primary and permanent teeth) · 8-12 mo Nonrestorative Treatments for Caries: Systematic Review and Network Meta-analysis. (2019) | RR 3.2 [2.24, 4.56] | 7 studies · 1575 participants | Moderate |
5% NaF varnish vs Sealant Arrest or reversal of noncavitated occlusal carious lesions · Children and adults with noncavitated carious lesions on occlusal surfaces (primary and permanent teeth) · 8-12 mo Nonrestorative Treatments for Caries: Systematic Review and Network Meta-analysis. (2019) | RR 0.99 [0.86, 1.15] | 7 studies · 1575 participants | Low |
2400 to 2800 ppm F toothpaste vs 440 to 550 ppm F toothpaste Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | SMD -0.29 [-0.49, -0.08] | NR | Low |
Pulpotomy vs Pulpectomy Soft tissue pathology · Children with carious vital pulp exposure in primary incisors · Longest follow-up Pulpotomy versus pulpectomy in the treatment of vital pulp exposure in primary incisors. A systematic review… (2019) | RR 3.11 [0.54, 17.7] | NR | Ungraded |
Residence in weakly contaminated area (approx. 1-5 Ci/km2) vs Residence in non-contaminated (non-exposed) area (<1 Ci/km2) Dental caries experience (DMFT/dmft index) · Children aged 5-7 years (early school-age) · weak contamination A systematic review of the caries prevalence among children living in Chernobyl fallout countries. (2019) | WMD 4.65 [4.50, 4.80] | 1 study · 165 participants | Ungraded |
Flossing plus toothbrushing vs Toothbrushing alone Plaque · Adults, 16 years and older (dentate) · 1 month Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlling… (2019) · Cochrane | SMD -0.42 [-0.85, 0.02] | 7 studies · 542 participants | Very low |
Dental cavity liner (e.g. calcium hydroxide, glass ionomer, resin-modified glass ionomer, or flowable composite) placed under the restoration vs No liner (resin-based composite bonded directly to the tooth) Postoperative hypersensitivity (POH), cold response measurement (VAS score) · Adults or children with a Class I or Class II resin-based composite restoration in a permanent posterior tooth · 1 week Dental cavity liners for Class I and Class II resin‐based composite restorations (2019) · Cochrane | MD -0.20 [-0.67, 0.26] | 2 studies | Ungraded |
Longitudinal follow-up over time (natural caries progression; no assigned intervention) vs Within-cohort change from baseline to follow-up (>=3 y) Annual decline in percentage of caries-free participants (permanent dentition, D3) · Children and adolescents (permanent dentition, D3, up to 21 y), Western or comparable populations · Annual (studies with >=3 y follow-up), Baseline caries experience: high Caries Progression Rates Revisited: A Systematic Review. (2019) | 0.8% to 2.2% | 2 studies · 5029 participants | Ungraded |
Resin infiltration + 5% NaF varnish vs Sealant Arrest or reversal of noncavitated approximal carious lesions · Children and adults with noncavitated carious lesions on approximal surfaces (primary and permanent teeth) · 12-36 mo Nonrestorative Treatments for Caries: Systematic Review and Network Meta-analysis. (2019) | RR 1.91 [0.48, 7.52] | 6 studies · 565 participants | Very low |
Residence in heavily contaminated area (approx. 15-40 Ci/km2) vs Residence in non-contaminated (non-exposed) area (<1 Ci/km2) Dental caries experience (DMFT/dmft index) · Children of mixed ages (mean approximately 12 years; no age separation) · heavy contamination A systematic review of the caries prevalence among children living in Chernobyl fallout countries. (2019) | WMD 1.92 [1.87, 1.97] | 1 study · 600 participants | Ungraded |
1000 to 1250 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste Proportion developing new caries · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Follow-up: 12 to 60 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | RR 0.9 [0.77, 1.06] | 7 studies · 1898 participants | Low |
Higher JIA disease activity/severity (e.g., high JADAS/activity scores, polyarticular RF-negative subtype, active disease, anti-TNFalpha or cyclosporine medication) vs Lower JIA disease activity / inactive or milder JIA Prevalence and severity of oral and TMJ diseases/conditions (periodontal status and dental caries) · Children and adolescents with juvenile idiopathic arthritis (JIA) Oral health in children and adolescents with juvenile idiopathic arthritis - a systematic review and… (2019) | Higher JIA disease activity/severity was associated with worse oral outcomes in several studies: JADAS and global activity scores correlated positively with DMFT and gingival indices [27]; a polyarticular RF-negative… | NR | Ungraded |
Juvenile idiopathic arthritis (JIA) vs Children and adolescents without JIA (healthy peers) Dental maturation (tooth calcification) · Children and adolescents with juvenile idiopathic arthritis (JIA) Oral health in children and adolescents with juvenile idiopathic arthritis - a systematic review and… (2019) | Two studies gave divergent results: Lehtinen et al. [24] documented more advanced dental development in children with JIA, whereas Ley et al. [40] found dental maturity within the norms of healthy peers. | 2 studies | Ungraded |
0.2% NaF mouthrinse + supervised toothbrushing vs Sealant + 5% NaF varnish Arrest or reversal of noncavitated occlusal carious lesions · Children and adults with noncavitated carious lesions on occlusal surfaces (primary and permanent teeth) · 8-12 mo Nonrestorative Treatments for Caries: Systematic Review and Network Meta-analysis. (2019) | RR 0.58 [0.43, 0.79] | 7 studies · 1575 participants | Moderate |
Pulpotomy vs Pulpectomy Pathological mobility · Children with carious vital pulp exposure in primary incisors · Longest follow-up Pulpotomy versus pulpectomy in the treatment of vital pulp exposure in primary incisors. A systematic review… (2019) | Pathologic mobility was not reported for any tooth in three trials (Howley, Aminabadi, Casas); only one tooth with pathological mobility was reported by Nguyen et al. Not pooled. | 4 studies | Ungraded |
Residence in heavily contaminated area (approx. 15-40 Ci/km2) vs Residence in non-contaminated (non-exposed) area (<1 Ci/km2) Dental caries experience (DMFT/dmft index) · Children aged 12-15 years (adolescents) · heavy contamination A systematic review of the caries prevalence among children living in Chernobyl fallout countries. (2019) | WMD 0.67 [0.50, 0.84] | 1 study · 79 participants | Ungraded |
10% CPP-ACP paste vs No treatment Arrest or reversal of noncavitated carious lesions on any coronal surface · Children and adults with noncavitated carious lesions on any coronal surface (primary and permanent teeth) · 9-12 mo Nonrestorative Treatments for Caries: Systematic Review and Network Meta-analysis. (2019) | RR 1.03 [0.9, 1.18] | 3 studies · 4672 participants | Low |
Rubber/elastomeric cleaning stick plus toothbrushing vs Interdental brushing plus toothbrushing Gingivitis (gingival index) · Adults, 16 years and older (dentate) · 4 to 6 weeks Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlling… (2019) · Cochrane | MD 0.10 [-0.32, 0.52] | 1 study · 61 participants | Very low |
Intraoral fluoride-releasing glass bead device attached to the brace vs 250 ppm F (daily) fluoride mouthrinse Adverse effects · Orthodontic patients of any age with fixed braces (new DLs assessed at debond) · At debond; follow-up 19 months Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment (2019) · Cochrane | Additional SoF Table 3. Adverse effects: current design of the fluoride glass bead inadequate; high attrition partly due to bead breakages ('an improved method of attachment is needed'). 37 participants (1 RCT, Luther… | 1 study · 37 participants | Very low |
10% CPP-ACP cream (+ 900-ppm NaF mouthrinse + 1,000-ppm NaF dentifrice) vs Placebo cream (+ 900-ppm NaF mouthrinse + 1,000-ppm NaF dentifrice) Arrest or reversal of noncavitated facial/lingual carious lesions · Children and adults with noncavitated carious lesions on facial/lingual surfaces (primary and permanent teeth) · 2 mo Nonrestorative Treatments for Caries: Systematic Review and Network Meta-analysis. (2019) | RR 1.12 [0.93, 1.36] | 1 study · 45 participants | Low |
Er:YAG laser preparation combined with acid-etching vs Acid-etching (phosphoric acid) alone Sealant retention rate (completely retained) · Children with permanent molars requiring pit-and-fissure sealants · 6 months The clinical effects of laser preparation of tooth surfaces for fissure sealants placement: a systematic… (2019) | OR 0.55 [0.23, 1.34] | 1 study · 42 participants | Ungraded |
Rubber/elastomeric cleaning stick plus toothbrushing vs Toothbrushing alone Harms and adverse effects · Adults, 16 years and older (dentate) Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlling… (2019) · Cochrane | Harms and adverse outcomes: Not reported (neither study reported on adverse effects). | 0 studies | No studies |
Chlorhexidine 0.12% mouthrinse vs Pre-treatment (baseline, same group) Mean plaque score (pre- vs post-treatment) · Medically healthy individuals (adults and children, 6-60 years) · Pre- vs post-treatment, Chlorhexidine concentration: 0.12% The antiplaque/anticariogenic efficacy of Salvadora persica (Miswak) mouthrinse in comparison to that of… (2019) | MD 1.79 [1.39, 2.19] | 2 studies · 126 participants | Ungraded |
Dental cavity liner (e.g. calcium hydroxide, glass ionomer, resin-modified glass ionomer, or flowable composite) placed under the restoration vs No liner (resin-based composite bonded directly to the tooth) Postoperative hypersensitivity (POH), patient-reported (VAS score) · Adults or children with a Class I or Class II resin-based composite restoration in a permanent posterior tooth · 1 week Dental cavity liners for Class I and Class II resin‐based composite restorations (2019) · Cochrane | MD -0.33 [-0.43, -0.23] | 1 study | Ungraded |
No intervention (single-arm cohort estimates) vs No comparator First dentine caries incidence rate per person-year at risk (D3) · Caries-free children and adolescents with permanent dentition · Follow-up of at least 3 years Caries Progression Rates Revisited: A Systematic Review. (2019) | Incidence rate per person-year at risk 0.06 [0.06, 0.06] | 1 study | Ungraded |
38% silver diamine fluoride vs Placebo Root carious lesions arrest · Older adults with root carious lesions (exposed root surfaces) Silver diamine fluoride for managing carious lesions: an umbrella review. (2019) | Prevented Fraction 100–725 | 2 studies | Ungraded |
Colour clinical examination (visual shade categorization: yellow, light brown, dark brown, black) vs Hardness clinical examination (tactile texture categorization: soft, medium/leathery, hard) Discriminant power for caries severity: mean difference in log10 CFU (microbial load) between lesion categories · Patients with dentine carious lesions (deciduous/permanent teeth; children and adults) · B/DB/LB-Y (colour) vs S/M-H (hardness) Reliability of colour and hardness clinical examinations in detecting dentine caries severity: a systematic… (2019) | WMD -4.446 [-5.241, -3.650] | 2 studies | Ungraded |
Er:YAG laser preparation combined with acid-etching vs Acid-etching (phosphoric acid) alone Sealant retention rate (completely retained) · Children with permanent molars requiring pit-and-fissure sealants · 18 months The clinical effects of laser preparation of tooth surfaces for fissure sealants placement: a systematic… (2019) | OR 0.41 [0.21, 0.80] | 1 study · 42 participants | Ungraded |
Rubber/elastomeric cleaning stick plus toothbrushing vs Toothbrushing alone Periodontitis (probing pocket depth) · Adults, 16 years and older (dentate) Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlling… (2019) · Cochrane | One study measured probing pocket depth but no data were reported (Graziani 2017 mentioned PPD as outcome but no data). | 1 study | Ungraded |
Pulpotomy vs Pulpectomy Pathological root resorption · Children with carious vital pulp exposure in primary incisors · Longest follow-up Pulpotomy versus pulpectomy in the treatment of vital pulp exposure in primary incisors. A systematic review… (2019) | RR 1.5 [0.56, 4.04] | 2 studies | Ungraded |
30% SDF solution (applied annually) vs 30% SDF solution (once weekly for 3 weeks) Arrest of advanced cavitated carious lesions on any coronal surface · Preschool children with advanced cavitated carious lesions on any coronal surface (primary teeth) · 12 mo Nonrestorative Treatments for Caries: Systematic Review and Network Meta-analysis. (2019) | RR 0.72 [0.56, 0.91] | 1 study · 309 participants | Moderate |
Laser enamel preparation alone (Er,Cr:YSGG or CO2 laser) vs Acid-etching (phosphoric acid) Sealant retention rate (completely retained) · Caries-free children to young adults with premolars/molars requiring pit-and-fissure sealants · 6 months The clinical effects of laser preparation of tooth surfaces for fissure sealants placement: a systematic… (2019) | OR 1.22 [0.69, 2.16] | 3 studies · 80 participants | Ungraded |
1450 to 1500 ppm F toothpaste vs 1000 to 1250 ppm F toothpaste Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | SMD -0.08 [-0.14, -0.01] | 10 studies | Moderate |
1700 to 2200 ppm F toothpaste vs 250 ppm F toothpaste Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | SMD -0.23 [-0.5, 0.05] | NR | Low |
Longer follow-up vs Shorter follow-up Annual increment in DMFT (D3) · Children and adolescents with permanent dentition · Per additional year of follow-up, Adjusted for bitewings age at baseline and baseline caries experience Caries Progression Rates Revisited: A Systematic Review. (2019) | Meta-regression beta per year of follow-up 0.23 [0.06, 0.40] | 13 studies · 24753 participants | Ungraded |
2400 to 2800 ppm F toothpaste vs 440 to 550 ppm F toothpaste Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | SMD -0.2 [-0.46, 0.05] | NR | Low |
440 to 550 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | SMD -0.12 [-0.31, 0.07] | 2 studies | Low |
38% SDF solution (applied annually) vs 12% SDF solution (applied annually) Arrest of advanced cavitated carious lesions on any coronal surface · Preschool children with advanced cavitated carious lesions on any coronal surface (primary teeth) · 30 mo Nonrestorative Treatments for Caries: Systematic Review and Network Meta-analysis. (2019) | RR 1.21 [1.13, 1.3] | 1 study · 799 participants | High |
Resin-modified glass ionomer cement for bonding orthodontic brackets vs Light-cured composite resin for bonding brackets Adverse effects · Orthodontic patients of any age with fixed braces (new DLs assessed at debond) · At debond; follow-up 17.6 months Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment (2019) · Cochrane | SoF 5. Adverse effects: no evidence that either intervention had adverse effects. 173 participants (1 RCT, Benson 2019); certainty LOW. | 1 study · 173 participants | Low |
1500 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste Caries increment, tooth index d(m)ft · Young children with primary (deciduous) dentition (aged 1 to 6 years at study start) · 12 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane | No studies reported poolable d(m)ft increment; Cahen 1982 reported a df-rate of 18.25% (n=708) in the 0 ppm group vs 13.64% (n=632, 1500 ppm SMFP) and 9.37% (n=668, amine fluoride) groups. | 1 study | Ungraded |
Wooden cleaning stick plus toothbrushing vs Toothbrushing alone Interproximal caries · Adults, 16 years and older (dentate) Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlling… (2019) · Cochrane | No included study assessed caries as an outcome. | 0 studies | No studies |
CPP-ACP agent (e.g., GC Tooth Mousse) vs Control (no treatment / negative control) Average enamel surface roughness · Extracted human teeth with early/artificial enamel lesions (in vitro) · 24 hours to 28 days Evaluation of the efficacy of casein phosphopeptide-amorphous calcium phosphate on remineralization of white… (2019) | SMD -8.21 [-10.37, -6.04] | 3 studies · 56 participants | Ungraded |
Salvadora persica (miswak) mouthrinse vs Pre-treatment (baseline, same group) Mean plaque score (pre- vs post-treatment) · Medically healthy individuals (adults and children, 6-60 years) · Pre- vs post-treatment The antiplaque/anticariogenic efficacy of Salvadora persica (Miswak) mouthrinse in comparison to that of… (2019) | MD 0.46 [0.29, 0.63] | 12 studies · 310 participants | Ungraded |
Residence in heavily contaminated area (approx. 15-40 Ci/km2) vs Residence in non-contaminated (non-exposed) area (<1 Ci/km2) Dental caries experience (DMFT/dmft index) · Children aged 12-15 years (adolescents) · heavy contamination A systematic review of the caries prevalence among children living in Chernobyl fallout countries. (2019) | WMD 4.45 [3.99, 4.91] | 1 study · 265 participants | Ungraded |