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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

Limit to evidence status or GRADE (optional)

5,762 questions in 263 reviews · Dental caries

current versions
No studies 321 · 5.6%Ungraded 4,450 · 77.2%Very low 455 · 7.9%Low 297 · 5.2%Moderate 200 · 3.5%High 39 · 0.7%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Longitudinal follow-up over time (natural caries progression; no assigned intervention) vs Within-cohort change from baseline to follow-up (>=3 y)
Annual increment in DMFS (permanent dentition) · Children and adolescents (permanent dentition, D3, up to 21 y), Western or comparable populations · Per year of follow-up, Baseline caries experience: moderate
Caries Progression Rates Revisited: A Systematic Review. (2019)
0.23 to 1.2313 studies · 16473 participantsUngraded
Resin infiltration vs No treatment
Arrest or reversal of noncavitated approximal carious lesions · Children and adults with noncavitated carious lesions on approximal surfaces (primary and permanent teeth) · 12-36 mo
Nonrestorative Treatments for Caries: Systematic Review and Network Meta-analysis. (2019)
RR 2.11 [1.08, 4.13]6 studies · 565 participantsLow
Longitudinal follow-up over time (natural caries progression; no assigned intervention) vs Within-cohort change from baseline to follow-up (>=3 y)
Annual increment in DMFT (permanent dentition) · Children and adolescents (permanent dentition, D3, up to 21 y), Western or comparable populations · Per year of follow-up, Baseline caries experience: high
Caries Progression Rates Revisited: A Systematic Review. (2019)
0.391 study · 4380 participantsUngraded
Salvadora persica (miswak) mouthrinse vs Placebo rinse
Post-intervention mean plaque score · Medically healthy individuals (adults and children, 6-60 years) · Post-intervention
The antiplaque/anticariogenic efficacy of Salvadora persica (Miswak) mouthrinse in comparison to that of… (2019)
MD -0.59 [-0.82, -0.35]12 studies · 452 participantsUngraded
Dental cavity liner (e.g. calcium hydroxide, glass ionomer, resin-modified glass ionomer, or flowable composite) placed under the restoration vs No liner (resin-based composite bonded directly to the tooth)
Cost of materials · Adults or children with a Class I or Class II resin-based composite restoration in a permanent posterior tooth
Dental cavity liners for Class I and Class II resin‐based composite restorations (2019) · Cochrane
One study (Strober 2013) reported cost, concluding that eliminating a resin-modified glass ionomer lining could save approximately USD 4.50 per filling (about USD 2000 per dentist per year). No comparative effect…1 studyUngraded
Intervention NR
Care index, primary teeth · Disability: autism
Dental caries experience, care index and restorative index in children with learning disabilities and… (2019)
no estimate extracted2 studiesUngraded
Resin infiltration + 5% NaF varnish vs No treatment
Arrest or reversal of noncavitated occlusal carious lesions · Children and adults with noncavitated carious lesions on occlusal surfaces (primary and permanent teeth) · 8-12 mo
Nonrestorative Treatments for Caries: Systematic Review and Network Meta-analysis. (2019)
RR 3.2 [2.24, 4.56]7 studies · 1575 participantsModerate
5% NaF varnish vs Sealant
Arrest or reversal of noncavitated occlusal carious lesions · Children and adults with noncavitated carious lesions on occlusal surfaces (primary and permanent teeth) · 8-12 mo
Nonrestorative Treatments for Caries: Systematic Review and Network Meta-analysis. (2019)
RR 0.99 [0.86, 1.15]7 studies · 1575 participantsLow
2400 to 2800 ppm F toothpaste vs 440 to 550 ppm F toothpaste
Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months
Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane
SMD -0.29 [-0.49, -0.08]NRLow
Pulpotomy vs Pulpectomy
Soft tissue pathology · Children with carious vital pulp exposure in primary incisors · Longest follow-up
Pulpotomy versus pulpectomy in the treatment of vital pulp exposure in primary incisors. A systematic review… (2019)
RR 3.11 [0.54, 17.7]NRUngraded
Residence in weakly contaminated area (approx. 1-5 Ci/km2) vs Residence in non-contaminated (non-exposed) area (<1 Ci/km2)
Dental caries experience (DMFT/dmft index) · Children aged 5-7 years (early school-age) · weak contamination
A systematic review of the caries prevalence among children living in Chernobyl fallout countries. (2019)
WMD 4.65 [4.50, 4.80]1 study · 165 participantsUngraded
Flossing plus toothbrushing vs Toothbrushing alone
Plaque · Adults, 16 years and older (dentate) · 1 month
Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlling… (2019) · Cochrane
SMD -0.42 [-0.85, 0.02]7 studies · 542 participantsVery low
Dental cavity liner (e.g. calcium hydroxide, glass ionomer, resin-modified glass ionomer, or flowable composite) placed under the restoration vs No liner (resin-based composite bonded directly to the tooth)
Postoperative hypersensitivity (POH), cold response measurement (VAS score) · Adults or children with a Class I or Class II resin-based composite restoration in a permanent posterior tooth · 1 week
Dental cavity liners for Class I and Class II resin‐based composite restorations (2019) · Cochrane
MD -0.20 [-0.67, 0.26]2 studiesUngraded
Longitudinal follow-up over time (natural caries progression; no assigned intervention) vs Within-cohort change from baseline to follow-up (>=3 y)
Annual decline in percentage of caries-free participants (permanent dentition, D3) · Children and adolescents (permanent dentition, D3, up to 21 y), Western or comparable populations · Annual (studies with >=3 y follow-up), Baseline caries experience: high
Caries Progression Rates Revisited: A Systematic Review. (2019)
0.8% to 2.2%2 studies · 5029 participantsUngraded
Resin infiltration + 5% NaF varnish vs Sealant
Arrest or reversal of noncavitated approximal carious lesions · Children and adults with noncavitated carious lesions on approximal surfaces (primary and permanent teeth) · 12-36 mo
Nonrestorative Treatments for Caries: Systematic Review and Network Meta-analysis. (2019)
RR 1.91 [0.48, 7.52]6 studies · 565 participantsVery low
Residence in heavily contaminated area (approx. 15-40 Ci/km2) vs Residence in non-contaminated (non-exposed) area (<1 Ci/km2)
Dental caries experience (DMFT/dmft index) · Children of mixed ages (mean approximately 12 years; no age separation) · heavy contamination
A systematic review of the caries prevalence among children living in Chernobyl fallout countries. (2019)
WMD 1.92 [1.87, 1.97]1 study · 600 participantsUngraded
1000 to 1250 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste
Proportion developing new caries · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Follow-up: 12 to 60 months
Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane
RR 0.9 [0.77, 1.06]7 studies · 1898 participantsLow
Higher JIA disease activity/severity (e.g., high JADAS/activity scores, polyarticular RF-negative subtype, active disease, anti-TNFalpha or cyclosporine medication) vs Lower JIA disease activity / inactive or milder JIA
Prevalence and severity of oral and TMJ diseases/conditions (periodontal status and dental caries) · Children and adolescents with juvenile idiopathic arthritis (JIA)
Oral health in children and adolescents with juvenile idiopathic arthritis - a systematic review and… (2019)
Higher JIA disease activity/severity was associated with worse oral outcomes in several studies: JADAS and global activity scores correlated positively with DMFT and gingival indices [27]; a polyarticular RF-negative…NRUngraded
Juvenile idiopathic arthritis (JIA) vs Children and adolescents without JIA (healthy peers)
Dental maturation (tooth calcification) · Children and adolescents with juvenile idiopathic arthritis (JIA)
Oral health in children and adolescents with juvenile idiopathic arthritis - a systematic review and… (2019)
Two studies gave divergent results: Lehtinen et al. [24] documented more advanced dental development in children with JIA, whereas Ley et al. [40] found dental maturity within the norms of healthy peers.2 studiesUngraded
0.2% NaF mouthrinse + supervised toothbrushing vs Sealant + 5% NaF varnish
Arrest or reversal of noncavitated occlusal carious lesions · Children and adults with noncavitated carious lesions on occlusal surfaces (primary and permanent teeth) · 8-12 mo
Nonrestorative Treatments for Caries: Systematic Review and Network Meta-analysis. (2019)
RR 0.58 [0.43, 0.79]7 studies · 1575 participantsModerate
Pulpotomy vs Pulpectomy
Pathological mobility · Children with carious vital pulp exposure in primary incisors · Longest follow-up
Pulpotomy versus pulpectomy in the treatment of vital pulp exposure in primary incisors. A systematic review… (2019)
Pathologic mobility was not reported for any tooth in three trials (Howley, Aminabadi, Casas); only one tooth with pathological mobility was reported by Nguyen et al. Not pooled.4 studiesUngraded
Residence in heavily contaminated area (approx. 15-40 Ci/km2) vs Residence in non-contaminated (non-exposed) area (<1 Ci/km2)
Dental caries experience (DMFT/dmft index) · Children aged 12-15 years (adolescents) · heavy contamination
A systematic review of the caries prevalence among children living in Chernobyl fallout countries. (2019)
WMD 0.67 [0.50, 0.84]1 study · 79 participantsUngraded
10% CPP-ACP paste vs No treatment
Arrest or reversal of noncavitated carious lesions on any coronal surface · Children and adults with noncavitated carious lesions on any coronal surface (primary and permanent teeth) · 9-12 mo
Nonrestorative Treatments for Caries: Systematic Review and Network Meta-analysis. (2019)
RR 1.03 [0.9, 1.18]3 studies · 4672 participantsLow
Rubber/elastomeric cleaning stick plus toothbrushing vs Interdental brushing plus toothbrushing
Gingivitis (gingival index) · Adults, 16 years and older (dentate) · 4 to 6 weeks
Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlling… (2019) · Cochrane
MD 0.10 [-0.32, 0.52]1 study · 61 participantsVery low
Intraoral fluoride-releasing glass bead device attached to the brace vs 250 ppm F (daily) fluoride mouthrinse
Adverse effects · Orthodontic patients of any age with fixed braces (new DLs assessed at debond) · At debond; follow-up 19 months
Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment (2019) · Cochrane
Additional SoF Table 3. Adverse effects: current design of the fluoride glass bead inadequate; high attrition partly due to bead breakages ('an improved method of attachment is needed'). 37 participants (1 RCT, Luther…1 study · 37 participantsVery low
10% CPP-ACP cream (+ 900-ppm NaF mouthrinse + 1,000-ppm NaF dentifrice) vs Placebo cream (+ 900-ppm NaF mouthrinse + 1,000-ppm NaF dentifrice)
Arrest or reversal of noncavitated facial/lingual carious lesions · Children and adults with noncavitated carious lesions on facial/lingual surfaces (primary and permanent teeth) · 2 mo
Nonrestorative Treatments for Caries: Systematic Review and Network Meta-analysis. (2019)
RR 1.12 [0.93, 1.36]1 study · 45 participantsLow
Er:YAG laser preparation combined with acid-etching vs Acid-etching (phosphoric acid) alone
Sealant retention rate (completely retained) · Children with permanent molars requiring pit-and-fissure sealants · 6 months
The clinical effects of laser preparation of tooth surfaces for fissure sealants placement: a systematic… (2019)
OR 0.55 [0.23, 1.34]1 study · 42 participantsUngraded
Rubber/elastomeric cleaning stick plus toothbrushing vs Toothbrushing alone
Harms and adverse effects · Adults, 16 years and older (dentate)
Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlling… (2019) · Cochrane
Harms and adverse outcomes: Not reported (neither study reported on adverse effects).0 studiesNo studies
Chlorhexidine 0.12% mouthrinse vs Pre-treatment (baseline, same group)
Mean plaque score (pre- vs post-treatment) · Medically healthy individuals (adults and children, 6-60 years) · Pre- vs post-treatment, Chlorhexidine concentration: 0.12%
The antiplaque/anticariogenic efficacy of Salvadora persica (Miswak) mouthrinse in comparison to that of… (2019)
MD 1.79 [1.39, 2.19]2 studies · 126 participantsUngraded
Dental cavity liner (e.g. calcium hydroxide, glass ionomer, resin-modified glass ionomer, or flowable composite) placed under the restoration vs No liner (resin-based composite bonded directly to the tooth)
Postoperative hypersensitivity (POH), patient-reported (VAS score) · Adults or children with a Class I or Class II resin-based composite restoration in a permanent posterior tooth · 1 week
Dental cavity liners for Class I and Class II resin‐based composite restorations (2019) · Cochrane
MD -0.33 [-0.43, -0.23]1 studyUngraded
No intervention (single-arm cohort estimates) vs No comparator
First dentine caries incidence rate per person-year at risk (D3) · Caries-free children and adolescents with permanent dentition · Follow-up of at least 3 years
Caries Progression Rates Revisited: A Systematic Review. (2019)
Incidence rate per person-year at risk 0.06 [0.06, 0.06]1 studyUngraded
38% silver diamine fluoride vs Placebo
Root carious lesions arrest · Older adults with root carious lesions (exposed root surfaces)
Silver diamine fluoride for managing carious lesions: an umbrella review. (2019)
Prevented Fraction 100–7252 studiesUngraded
Colour clinical examination (visual shade categorization: yellow, light brown, dark brown, black) vs Hardness clinical examination (tactile texture categorization: soft, medium/leathery, hard)
Discriminant power for caries severity: mean difference in log10 CFU (microbial load) between lesion categories · Patients with dentine carious lesions (deciduous/permanent teeth; children and adults) · B/DB/LB-Y (colour) vs S/M-H (hardness)
Reliability of colour and hardness clinical examinations in detecting dentine caries severity: a systematic… (2019)
WMD -4.446 [-5.241, -3.650]2 studiesUngraded
Er:YAG laser preparation combined with acid-etching vs Acid-etching (phosphoric acid) alone
Sealant retention rate (completely retained) · Children with permanent molars requiring pit-and-fissure sealants · 18 months
The clinical effects of laser preparation of tooth surfaces for fissure sealants placement: a systematic… (2019)
OR 0.41 [0.21, 0.80]1 study · 42 participantsUngraded
Rubber/elastomeric cleaning stick plus toothbrushing vs Toothbrushing alone
Periodontitis (probing pocket depth) · Adults, 16 years and older (dentate)
Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlling… (2019) · Cochrane
One study measured probing pocket depth but no data were reported (Graziani 2017 mentioned PPD as outcome but no data).1 studyUngraded
Pulpotomy vs Pulpectomy
Pathological root resorption · Children with carious vital pulp exposure in primary incisors · Longest follow-up
Pulpotomy versus pulpectomy in the treatment of vital pulp exposure in primary incisors. A systematic review… (2019)
RR 1.5 [0.56, 4.04]2 studiesUngraded
30% SDF solution (applied annually) vs 30% SDF solution (once weekly for 3 weeks)
Arrest of advanced cavitated carious lesions on any coronal surface · Preschool children with advanced cavitated carious lesions on any coronal surface (primary teeth) · 12 mo
Nonrestorative Treatments for Caries: Systematic Review and Network Meta-analysis. (2019)
RR 0.72 [0.56, 0.91]1 study · 309 participantsModerate
Laser enamel preparation alone (Er,Cr:YSGG or CO2 laser) vs Acid-etching (phosphoric acid)
Sealant retention rate (completely retained) · Caries-free children to young adults with premolars/molars requiring pit-and-fissure sealants · 6 months
The clinical effects of laser preparation of tooth surfaces for fissure sealants placement: a systematic… (2019)
OR 1.22 [0.69, 2.16]3 studies · 80 participantsUngraded
1450 to 1500 ppm F toothpaste vs 1000 to 1250 ppm F toothpaste
Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months
Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane
SMD -0.08 [-0.14, -0.01]10 studiesModerate
1700 to 2200 ppm F toothpaste vs 250 ppm F toothpaste
Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months
Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane
SMD -0.23 [-0.5, 0.05]NRLow
Longer follow-up vs Shorter follow-up
Annual increment in DMFT (D3) · Children and adolescents with permanent dentition · Per additional year of follow-up, Adjusted for bitewings age at baseline and baseline caries experience
Caries Progression Rates Revisited: A Systematic Review. (2019)
Meta-regression beta per year of follow-up 0.23 [0.06, 0.40]13 studies · 24753 participantsUngraded
2400 to 2800 ppm F toothpaste vs 440 to 550 ppm F toothpaste
Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months
Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane
SMD -0.2 [-0.46, 0.05]NRLow
440 to 550 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste
Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months
Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane
SMD -0.12 [-0.31, 0.07]2 studiesLow
38% SDF solution (applied annually) vs 12% SDF solution (applied annually)
Arrest of advanced cavitated carious lesions on any coronal surface · Preschool children with advanced cavitated carious lesions on any coronal surface (primary teeth) · 30 mo
Nonrestorative Treatments for Caries: Systematic Review and Network Meta-analysis. (2019)
RR 1.21 [1.13, 1.3]1 study · 799 participantsHigh
Resin-modified glass ionomer cement for bonding orthodontic brackets vs Light-cured composite resin for bonding brackets
Adverse effects · Orthodontic patients of any age with fixed braces (new DLs assessed at debond) · At debond; follow-up 17.6 months
Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment (2019) · Cochrane
SoF 5. Adverse effects: no evidence that either intervention had adverse effects. 173 participants (1 RCT, Benson 2019); certainty LOW.1 study · 173 participantsLow
1500 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste
Caries increment, tooth index d(m)ft · Young children with primary (deciduous) dentition (aged 1 to 6 years at study start) · 12 months
Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane
No studies reported poolable d(m)ft increment; Cahen 1982 reported a df-rate of 18.25% (n=708) in the 0 ppm group vs 13.64% (n=632, 1500 ppm SMFP) and 9.37% (n=668, amine fluoride) groups.1 studyUngraded
Wooden cleaning stick plus toothbrushing vs Toothbrushing alone
Interproximal caries · Adults, 16 years and older (dentate)
Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlling… (2019) · Cochrane
No included study assessed caries as an outcome.0 studiesNo studies
CPP-ACP agent (e.g., GC Tooth Mousse) vs Control (no treatment / negative control)
Average enamel surface roughness · Extracted human teeth with early/artificial enamel lesions (in vitro) · 24 hours to 28 days
Evaluation of the efficacy of casein phosphopeptide-amorphous calcium phosphate on remineralization of white… (2019)
SMD -8.21 [-10.37, -6.04]3 studies · 56 participantsUngraded
Salvadora persica (miswak) mouthrinse vs Pre-treatment (baseline, same group)
Mean plaque score (pre- vs post-treatment) · Medically healthy individuals (adults and children, 6-60 years) · Pre- vs post-treatment
The antiplaque/anticariogenic efficacy of Salvadora persica (Miswak) mouthrinse in comparison to that of… (2019)
MD 0.46 [0.29, 0.63]12 studies · 310 participantsUngraded
Residence in heavily contaminated area (approx. 15-40 Ci/km2) vs Residence in non-contaminated (non-exposed) area (<1 Ci/km2)
Dental caries experience (DMFT/dmft index) · Children aged 12-15 years (adolescents) · heavy contamination
A systematic review of the caries prevalence among children living in Chernobyl fallout countries. (2019)
WMD 4.45 [3.99, 4.91]1 study · 265 participantsUngraded