Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

332 questions · 335 findings · 55 reviews · Headline outcomes only

No studies found 77 · 23%GRADE not reported 3 · 0.9%Very low 113 · 33.7%Low 75 · 22.4%Moderate 61 · 18.2%High 6 · 1.8%

Fecal microbiota transplantation vs control

Maintenance of endoscopic remission in UC (RR > 1 favors FMT) · Patients with quiescent ulcerative colitis

It is very uncertain whether fecal microbiota transplantation changes maintenance of endoscopic remission in UC (RR > 1 favors FMT) compared with control (very low certainty).

1 finding from 1 review

Oral 5‐aminosalicylic acid vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Failure to maintain clinical or endoscopic remission · Patients with quiescent ulcerative colitis

Oral 5‐aminosalicylic acid showed no clear difference in failure to maintain clinical or endoscopic remission compared with comparator 5‐aminosalicylic acid formulation (low certainty).

1 finding from 1 review

Intensification of prophylactic therapy guided by colonoscopy vs intensification guided by clinical recurrence

Endoscopic recurrence · adult participants (> 16 years of age) undergoing intestinal resection due to Crohn's disease

Intensification of prophylactic therapy guided by colonoscopy may leads to lower endoscopic recurrence ( compared with intensification guided by clinical recurrence (low certainty).

1 finding from 1 review

Initiation of prophylactic therapy guided by colonoscopy vs initiation of prophylactic therapy immediately after surgery

Endoscopic recurrence · adult participants (> 16 years of age) undergoing intestinal resection due to Crohn's disease

It is very uncertain whether initiation of prophylactic therapy guided by colonoscopy changes endoscopic recurrence (at week 102) compared with initiation of prophylactic therapy immediately after surgery (very low certainty).

1 finding from 1 review

Adalimumab vs placebo

Failure to maintain endoscopic remission · Participants with Crohn's disease in remission

Adalimumab probably leads to lower failure to maintain endoscopic remission compared with placebo (moderate certainty).

1 finding from 1 review

Adalimumab vs placebo

Failure to maintain clinical or endoscopic response with prior TNF‐α antagonist exposure · Participants with Crohn's disease in remission

Adalimumab probably leads to lower failure to maintain clinical or endoscopic response with prior TNF‐α… compared with placebo (moderate certainty).

1 finding from 1 review

Adalimumab vs active comparators

Failure to maintain endoscopic remission · People with quiescent Crohn's disease (ileocolic resection)

It is very uncertain whether adalimumab changes failure to maintain endoscopic remission compared with active comparator (very low certainty).

1 finding from 1 review