Cochrane · systematic review · CD012328
Colonoscopy‐guided therapy for the prevention of post‐operative recurrence of Crohn’s disease
Candia, R, Bravo-Soto, GA, Monrroy, H, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
GutAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
8
No studies
2
Included studies
NR
No studies 2 · 16.7%Ungraded 2 · 16.7%Very low 6 · 50%Low 2 · 16.7%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Intensification of prophylactic therapy guided by colonoscopy compared to intensification guided by clinical recurrence for the prevention of postoperative recurrence of Crohn’s disease
Population: adult participants (> 16 years of age) undergoing intestinal resection due to Crohn's disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical recurrence ( Intensification of prophylactic therapy guided by colonoscopy vs intensification guided by clinical recurrence | RR 0.82 [0.56, 1.18] | 1 study · 174 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Endoscopic recurrence ( Intensification of prophylactic therapy guided by colonoscopy vs intensification guided by clinical recurrence | RR 0.73 [0.56, 0.95] | 1 study · 174 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Surgical recurrence ( Intensification of prophylactic therapy guided by colonoscopy vs intensification guided by clinical recurrence | no estimate extracted | 504 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Mortality ( Intensification of prophylactic therapy guided by colonoscopy vs intensification guided by clinical recurrence | no estimate extracted | 1 study · 174 participants | Ungraded |
Quality of life Intensification of prophylactic therapy guided by colonoscopy vs intensification guided by clinical recurrence | no estimate extracted | NR | No studies |
Adverse effects ( Intensification of prophylactic therapy guided by colonoscopy vs intensification guided by clinical recurrence | RR 0.78 [0.49, 1.25] | 1 study · 174 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Initiation of prophylactic therapy guided by colonoscopy compared to initiation of prophylactic therapy immediately after surgery for the prevention of postoperative recurrence of Crohn’s disease
Population: Adult participants (> 16 years of age) undergoing intestinal resection due to Crohn's disease.
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical recurrence (until week 102) Initiation of prophylactic therapy guided by colonoscopy vs initiation of prophylactic therapy immediately after surgery | RR 1.16 [0.73, 1.84] | 1 study · 63 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Endoscopic recurrence (at week 102) Initiation of prophylactic therapy guided by colonoscopy vs initiation of prophylactic therapy immediately after surgery | RR 1.16 [0.73, 1.84] | 1 study · 63 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Surgical recurrence ( Initiation of prophylactic therapy guided by colonoscopy vs initiation of prophylactic therapy immediately after surgery | RR 0.79 [0.38, 1.62] | 133 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Mortality ( Initiation of prophylactic therapy guided by colonoscopy vs initiation of prophylactic therapy immediately after surgery | no estimate extracted | 1 study · 63 participants | Ungraded |
Quality of life Initiation of prophylactic therapy guided by colonoscopy vs initiation of prophylactic therapy immediately after surgery | no estimate extracted | NR | No studies |
Adverse effects ( Initiation of prophylactic therapy guided by colonoscopy vs initiation of prophylactic therapy immediately after surgery | RR 0.58 [0.42, 0.82] | 1 study · 63 participants | Very low Downgraded: risk of bias, imprecision, indirectness |