What do systematic reviews say?

Early discharge vs standard discharge

Early discharge showed no clear difference in women readmitted within 6 weeks compared with standard discharge (moderate certainty).

• Early postnatal discharge from hospital for healthy mothers and term infants 2021 · Cochrane Headline outcomes only
  RR 1.12 [0.82, 1.54]
  11 studies · 6992 participants
  Moderate

Early discharge vs standard discharge

The review found no eligible studies for this question.

• Early postnatal discharge from hospital for healthy mothers and term infants 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Early discharge vs standard discharge

Early discharge showed no clear difference in women probably depressed within 6 months compared with standard discharge (low certainty).

• Early postnatal discharge from hospital for healthy mothers and term infants 2021 · Cochrane Headline outcomes only
  RR 0.8 [0.46, 1.42]
  5 studies · 4333 participants
  Low

Early discharge vs standard discharge

Early discharge showed no clear difference in women breastfeeding (exclusively or partially) at 6 weeks postpartum compared with standard discharge (moderate certainty).

• Early postnatal discharge from hospital for healthy mothers and term infants 2021 · Cochrane Headline outcomes only
  RR 1.04 [0.96, 1.13]
  10 studies · 7156 participants
  Moderate

Early discharge vs standard discharge

Early discharge showed no clear difference in number of women having contact with healthcare professionals… compared with standard discharge (moderate certainty).

• Early postnatal discharge from hospital for healthy mothers and term infants 2021 · Cochrane Headline outcomes only
  RR 0.72 [0.43, 1.2]
  2 studies · 464 participants
  Moderate

Early discharge vs standard discharge

• Early postnatal discharge from hospital for healthy mothers and term infants 2021 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 1011 participants
  Low

Early treatment vs expectant management

Early treatment showed no clear difference in all‐cause mortality during hospital stay compared with expectant management (moderate certainty).

• Early treatment versus expectant management of hemodynamically significant patent ductus arteriosus for preterm infants 2020 · Cochrane Headline outcomes only
  RR 0.8 [0.46, 1.39]
  6 studies · 500 participants
  Moderate

Early treatment vs expectant management

It is very uncertain whether early treatment changes proportion of infants requiring surgical PDA ligation or… compared with expectant management (very low certainty).

• Early treatment versus expectant management of hemodynamically significant patent ductus arteriosus for preterm infants 2020 · Cochrane Headline outcomes only
  RR 1.08 [0.65, 1.8]
  4 studies · 432 participants
  Very low

Early treatment vs expectant management

Early treatment may leads to higher proportion of infants receiving any pharmacotherapy for a… compared with expectant management (low certainty).

• Early treatment versus expectant management of hemodynamically significant patent ductus arteriosus for preterm infants 2020 · Cochrane Headline outcomes only
  RR 2.3 [1.86, 2.83]
  2 studies · 232 participants
  Low

Early treatment vs expectant management

Early treatment showed no clear difference in chronic lung disease compared with expectant management (moderate certainty).

• Early treatment versus expectant management of hemodynamically significant patent ductus arteriosus for preterm infants 2020 · Cochrane Headline outcomes only
  RR 0.9 [0.62, 1.29]
  4 studies · 339 participants
  Moderate

Early treatment vs expectant management

Early treatment showed no clear difference in severe Intraventricular hemorrhage (grades III and IV) compared with expectant management (low certainty).

• Early treatment versus expectant management of hemodynamically significant patent ductus arteriosus for preterm infants 2020 · Cochrane Headline outcomes only
  RR 0.83 [0.32, 2.16]
  2 studies · 171 participants
  Low

Early treatment vs expectant management

Early treatment showed no clear difference in necrotizing enterocolitis (NEC; stage 2 or greater) compared with expectant management (low certainty).

• Early treatment versus expectant management of hemodynamically significant patent ductus arteriosus for preterm infants 2020 · Cochrane Headline outcomes only
  RR 2.34 [0.86, 6.41]
  5 studies · 473 participants
  Low

Early hCG vs late hCG

Early hCG showed no clear difference in pregnancy rate per couple compared with late hCG (low certainty).

• Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
  OR 1.32 [0.77, 2.25]
  1 study · 612 participants
  Low

Early hCG vs late hCG

It is very uncertain whether early hCG changes miscarriage rate compared with late hCG (very low certainty).

• Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
  OR 0.51 [0.08, 3.28]
  1 study · 65 participants
  Very low

Early ART vs standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl)

Early ART probably leads to lower death compared with standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl) (moderate certainty).

• Optimal time for initiation of antiretroviral therapy in asymptomatic, HIV‐infected, treatment‐naive adults 2010 · Cochrane Headline outcomes only
  RR 0.26 [0.11, 0.62]
  2 studies · 1065 participants
  Moderate

Early ART vs standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl)

Early ART showed no clear difference in tuberculosis compared with standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl) (moderate certainty).

• Optimal time for initiation of antiretroviral therapy in asymptomatic, HIV‐infected, treatment‐naive adults 2010 · Cochrane Headline outcomes only
  RR 0.54 [0.26, 1.12]
  2 studies · 1065 participants
  Moderate

Early ART vs standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl)

Early ART showed no clear difference in disease progression measured by opportunistic disease Opportunistic… compared with standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl) (low certainty).

• Optimal time for initiation of antiretroviral therapy in asymptomatic, HIV‐infected, treatment‐naive adults 2010 · Cochrane Headline outcomes only
  OR 0.29 [0.03, 2.87]
  1 study · 249 participants
  Low

Early oral feeding vs delayed oral feeding

Early oral feeding showed no clear difference in postoperative ileus compared with delayed oral feeding (moderate certainty).

• Early versus delayed oral fluids and food for reducing complications after major abdominal gynaecologic surgery 2014 · Cochrane Headline outcomes only
  RR 0.47 [0.17, 1.29]
  3 studies · 279 participants
  Moderate

Early oral feeding vs delayed oral feeding

Early oral feeding showed no clear difference in nausea or vomiting or both compared with delayed oral feeding (moderate certainty).

• Early versus delayed oral fluids and food for reducing complications after major abdominal gynaecologic surgery 2014 · Cochrane Headline outcomes only
  RR 1.03 [0.64, 1.67]
  4 studies · 484 participants
  Moderate

Early oral feeding vs delayed oral feeding

• Early versus delayed oral fluids and food for reducing complications after major abdominal gynaecologic surgery 2014 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 338 participants
  Moderate