Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Extracted human permanent posterior teeth (premolars and molars), occlusal (pit-and-fissure) surfaces
In in vitro, fibre-optic transillumination pooled specificity was 0.97 (95% CI 0.89 to 0.994) for occlusal caries at the dentin detection level; ungraded.
4 findings from 1 review
Specificity 0.97 [0.89, 0.994]
2 studies
GRADE not reported
DOR 37.77 [13.69, 104.19]
2 studies
GRADE not reported
AUC 0.92
2 studies
GRADE not reported
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Lactobacilli presence (CFU > 10^5) · Adults undergoing orthodontic treatment
Aligners probably lower the risk of high lactobacilli counts versus fixed appliances in adults at 3 months (RR 0.09, 95% CI 0.02 to 0.47; low certainty).
2 findings from 1 review
Average fluorescence loss (dF%) · Adults undergoing orthodontic treatment
A single study reported lower average fluorescence (mineral) loss with aligners versus fixed appliances in adults at 3 months (MD -1.40, 95% CI -2.15 to -0.65; ungraded).
1 finding from 1 review
MD -1.40 [-2.15, -0.65]
1 study
GRADE not reported
All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies
Each additional lost tooth was associated with a multivariable-adjusted HR of 1.02 (95% CI 1.01 to 1.03) for all-cause mortality (11 studies, I2=89%), statistically significant; GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).
3 findings from 1 review
Diagnostic accuracy for proximal caries detection (caries detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro)
Under in vitro conditions, conventional D-speed bitewing radiography had a pooled diagnostic odds ratio of 5.2 (95% CI 1.6, 16.8) for proximal caries detection at the caries detection level; ungraded.
4 findings from 1 review
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Diagnostic accuracy for proximal caries detection (caries detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro)
Under in vitro conditions, visual examination had a pooled sensitivity of 0.64 (95% CI 0.42, 0.81) for proximal caries detection at the caries detection level; ungraded.
4 findings from 1 review
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Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Human permanent posterior teeth (premolars and molars) in patients, occlusal (pit-and-fissure) surfaces
In in vivo, laser fluorescence (DIAGNOdent 2095) pooled summary ROC AUC was 0.92 for occlusal caries at the dentin detection level; ungraded.
4 findings from 1 review
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Intervention not reported
Water samples with fluoride concentration below the acceptable range
1 finding from 1 review
Intervention not reported
Mean DMFT (decayed, missing, filled permanent teeth) · Individuals with permanent dentition in East Africa
Mean DMFT was lowest in Tanzania at 0.945 (95% CI not reported); certainty not graded.
1 finding from 1 review
Plaque · Adolescents/teenagers undergoing orthodontic treatment
A single study reported a lower full-mouth plaque score with aligners versus fixed appliances in adolescents at 12 months (MD -43.48, 95% CI -47.65 to -39.31; ungraded).
3 findings from 1 review
MD -43.48 [-47.65, -39.31]
1 study
GRADE not reported
MD -0.40 [-0.77, -0.03]
1 study
GRADE not reported
MD -14.78 [-16.74, -12.82]
1 study
GRADE not reported
Intervention not reported
Dental caries prevalence
1 finding from 1 review
Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Human permanent posterior teeth (premolars and molars) in patients, occlusal (pit-and-fissure) surfaces
In in vivo, conventional bitewing radiography (D-speed) pooled sensitivity was 0.79 (95% CI 0.41 to 0.96) for occlusal caries at the dentin detection level; ungraded.
4 findings from 1 review
Sensitivity 0.79 [0.41, 0.96]
2 studies
GRADE not reported
Specificity 0.75 [0.68, 0.82]
2 studies
GRADE not reported
AUC 0.77
2 studies
GRADE not reported
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DOR 11.79 [2.43, 57.24]
2 studies
GRADE not reported
Gingival index (GI) · Adolescents/teenagers undergoing orthodontic treatment
A single study reported lower gingival index with aligners versus fixed appliances in adolescents at 18 months (MD -0.57, 95% CI -0.93 to -0.21; ungraded).
1 finding from 1 review
MD -0.57 [-0.93, -0.21]
1 study
GRADE not reported
Diagnostic accuracy for proximal caries detection (caries detection level) · Patients with permanent posterior teeth, proximal surfaces assessed clinically (in vivo)
Under in vivo conditions, sensor-based digital bitewing radiography had a pooled specificity of 0.93 (95% CI 0.77, 0.98) for proximal caries detection at the caries detection level; ungraded.
4 findings from 1 review
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Dental caries prevalence · General Pakistani population (all ages and both sexes; predominantly children and adolescents)
Fixed-effect pooled dental caries prevalence was 57.0% (95% CI 56.4% to 57.6%).
1 finding from 1 review
Periodontitis (prevalence) · Adults (general and hospital populations assessed in case-control studies)
Periodontitis prevalence is significantly higher in systemic sclerosis patients than controls (OR 7.01); certainty ungraded.
1 finding from 1 review
OR 7.007 [3.529, 13.915]
3 studies
GRADE not reported
Diagnostic accuracy for proximal caries detection (1/3 dentin detection level) · Extracted permanent posterior teeth with proximal surfaces (in vitro)
Under in vitro conditions, conventional F-speed bitewing radiography had a summary ROC AUC of 0.98 for proximal caries detection at the 1/3 dentin detection level; ungraded.
4 findings from 1 review
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All-cause mortality (ACM) · Adults (any age) with a known number of remaining teeth, followed prospectively in cohort studies
In prospective cohorts, adults with 1-19 teeth had a higher cumulative incidence of all-cause mortality than adults with 20-32 teeth (RR 1.76, 95% CI 1.41 to 2.19; 8 cohort studies, I2=94%); GRADE per-analysis ratings reported in Supplementary File 7 (not available in provided sources).
1 finding from 1 review
Initiation of white spot lesions (WSL), visual-tactile assessment · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)
Glass ionomer cement did not show a statistically significant difference in new white spot lesions versus resin adhesive (very low certainty).
1 finding from 1 review
S. mutans presence (CFU > 10^5) · Adults undergoing orthodontic treatment
Aligners probably lower the risk of high S. mutans counts versus fixed appliances in adults at 3 months (RR 0.07, 95% CI 0.01 to 0.49; low certainty).
2 findings from 1 review