Gap finder

Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

Limit to evidence status or GRADE (optional)

3,601 questions in 252 reviews · Pregnancy and Childbirth

current versions
No studies 726 · 20.2%Ungraded 421 · 11.7%Very low 828 · 23%Low 993 · 27.6%Moderate 486 · 13.5%High 147 · 4.1%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Antibiotic vs placebo
Duration of admission to neonatal intensive care unit · Women with meconium‐stained amniotic fluid in labour, gestational age more than 24 weeks
Antibiotics for meconium‐stained amniotic fluid in labour for preventing maternal and neonatal infections (2014) · Cochrane
no estimate extractedNRNo studies
Any intervention to prevent violence (all interventions) vs standard care
Partner abuse: episodes during pregnancy · all pregnant women
Interventions for preventing or reducing domestic violence against pregnant women (2014) · Cochrane
RR 0.5 [0.25, 1.02]1 study · 220 participantsVery low
Any intervention to prevent violence (all interventions) vs standard care
Partner abuse: episodes during the first 3 months postpartum · all pregnant women
Interventions for preventing or reducing domestic violence against pregnant women (2014) · Cochrane
RR 0.6 [0.35, 1.04]1 study · 271 participantsVery low
Any intervention to prevent violence (all interventions) vs standard care
Partner abuse: abuse score in the first 3 months postpartum (Conflict Tactics Score*) The CTS is a 19‐item self‐report scale listing behaviours that the respondent’s partner might use in conflicts. Women report the frequency of partner behaviours ... · all pregnant women
Interventions for preventing or reducing domestic violence against pregnant women (2014) · Cochrane
no estimate extracted1 study · 46 participantsVery low
Any intervention to prevent violence (all interventions) vs standard care
Partner abuse in the first 3 months postpartum (Current Abuse Score**) The Current abuse score consists of 2 scales: 1) Abuse Assessment Screen (AAS) and 2) Prenatal Psychosocial Profile (PPP). · all pregnant women
Interventions for preventing or reducing domestic violence against pregnant women (2014) · Cochrane
no estimate extracted1 study · 191 participantsVery low
Any intervention to prevent violence (all interventions) vs standard care
Partner abuse: total episodes at final study assessment (pregnancy and up to 10 weeks postpartum) · all pregnant women
Interventions for preventing or reducing domestic violence against pregnant women (2014) · Cochrane
RR 0.62 [0.43, 0.88]1 study · 306 participantsModerate
Any intervention to prevent violence (all interventions) vs standard care
Number of low‐birthweight (< 2500 g) babies · all pregnant women
Interventions for preventing or reducing domestic violence against pregnant women (2014) · Cochrane
RR 0.74 [0.41, 1.32]1 study · 306 participantsLow
Prophylactic intravenous antibiotics administered before cesarean incision vs after neonatal umbilical cord clamping
Maternal composite morbidity · women undergoing cesarean delivery.
Timing of intravenous prophylactic antibiotics for preventing postpartum infectious morbidity in women… (2014) · Cochrane
RR 0.67 [0.54, 0.82]10 studies · 5041 participantsHigh
Prophylactic intravenous antibiotics administered before cesarean incision vs after neonatal umbilical cord clamping
Maternal endomyometritis · women undergoing cesarean delivery.
Timing of intravenous prophylactic antibiotics for preventing postpartum infectious morbidity in women… (2014) · Cochrane
RR 0.54 [0.36, 0.79]10 studies · 5041 participantsHigh
Prophylactic intravenous antibiotics administered before cesarean incision vs after neonatal umbilical cord clamping
Maternal wound Infection · women undergoing cesarean delivery.
Timing of intravenous prophylactic antibiotics for preventing postpartum infectious morbidity in women… (2014) · Cochrane
RR 0.59 [0.44, 0.81]10 studies · 5041 participantsHigh
Prophylactic intravenous antibiotics administered before cesarean incision vs after neonatal umbilical cord clamping
Maternal UTI/cystitis/pyelonephritis · women undergoing cesarean delivery.
Timing of intravenous prophylactic antibiotics for preventing postpartum infectious morbidity in women… (2014) · Cochrane
RR 1.02 [0.65, 1.59]8 studies · 4001 participantsModerate
Prophylactic intravenous antibiotics administered before cesarean incision vs after neonatal umbilical cord clamping
Maternal respiratory infection (pneumonia) · women undergoing cesarean delivery.
Timing of intravenous prophylactic antibiotics for preventing postpartum infectious morbidity in women… (2014) · Cochrane
RR 2.3 [0.34, 15.45]2 studies · 1158 participantsLow
Prophylactic intravenous antibiotics administered before cesarean incision vs after neonatal umbilical cord clamping
Neonatal sepsis · women undergoing cesarean delivery.
Timing of intravenous prophylactic antibiotics for preventing postpartum infectious morbidity in women… (2014) · Cochrane
RR 0.76 [0.51, 1.13]5 studies · 2907 participantsModerate
Prophylactic intravenous antibiotics administered before cesarean incision vs after neonatal umbilical cord clamping
Neonatal ICU admission · women undergoing cesarean delivery.
Timing of intravenous prophylactic antibiotics for preventing postpartum infectious morbidity in women… (2014) · Cochrane
RR 0.91 [0.74, 1.13]6 studies · 3708 participantsHigh
Ambroxol vs corticosteroid (betamethasone)
Incidence of RDS frequency in newborns · pregnant women at risk of preterm birth for preventing neonatal respiratory distress syndrome
Ambroxol for women at risk of preterm birth for preventing neonatal respiratory distress syndrome (2014) · Cochrane
RR 0.79 [0.59, 1.07]7 studies · 758 participantsModerate
Ambroxol vs corticosteroid (betamethasone)
Perinatal mortality frequency of deaths of newborns · pregnant women at risk of preterm birth for preventing neonatal respiratory distress syndrome
Ambroxol for women at risk of preterm birth for preventing neonatal respiratory distress syndrome (2014) · Cochrane
RR 0.51 [0.23, 1.12]6 studies · 657 participantsModerate
Ambroxol vs corticosteroid (betamethasone)
Adverse effects in pregnant women frequency in pregnant women · pregnant women at risk of preterm birth for preventing neonatal respiratory distress syndrome
Ambroxol for women at risk of preterm birth for preventing neonatal respiratory distress syndrome (2014) · Cochrane
RR 3.45 [0.34, 35.51]3 studies · 305 participantsVery low
Ambroxol vs placebo or no treatment
Incidence of RDS frequency in newborns · pregnant women at risk of preterm birth for preventing neonatal respiratory distress syndrome
Ambroxol for women at risk of preterm birth for preventing neonatal respiratory distress syndrome (2014) · Cochrane
RR 0.74 [0.46, 1.2]2 studies · 204 participantsLow
Ambroxol vs placebo or no treatment
Perinatal mortality frequency of deaths of newborns · pregnant women at risk of preterm birth for preventing neonatal respiratory distress syndrome
Ambroxol for women at risk of preterm birth for preventing neonatal respiratory distress syndrome (2014) · Cochrane
RR 0.61 [0.19, 1.98]1 study · 116 participantsLow
Ambroxol vs placebo or no treatment
Adverse effects in pregnant women frequency in pregnant women · pregnant women at risk of preterm birth for preventing neonatal respiratory distress syndrome
Ambroxol for women at risk of preterm birth for preventing neonatal respiratory distress syndrome (2014) · Cochrane
RR 1.79 [0.45, 7.13]1 study · 116 participantsLow
Ambroxol vs placebo or no treatment
Other events in newborns ‐ Administration of pulmonary surfactant frequency in newborns · pregnant women at risk of preterm birth for preventing neonatal respiratory distress syndrome
Ambroxol for women at risk of preterm birth for preventing neonatal respiratory distress syndrome (2014) · Cochrane
RR 1.19 [0.61, 2.3]1 study · 88 participantsLow
Ambroxol vs placebo or no treatment
Other events in newborns ‐ Need for mechanical ventilation frequency inf newborns · pregnant women at risk of preterm birth for preventing neonatal respiratory distress syndrome
Ambroxol for women at risk of preterm birth for preventing neonatal respiratory distress syndrome (2014) · Cochrane
RR 0.94 [0.73, 1.21]1 study · 88 participantsLow
Intervention NR
Manual removal of placenta Manual removal after intervention · women with retained placenta
Prostaglandins for management of retained placenta (2014) · Cochrane
RR 0.82 [0.54, 1.27]3 studies · 244 participantsVery low
Intervention NR
Severe postpartum haemorrhage Objectively or subjectively measured after intervention/Estimated blood loss in ML. · women with retained placenta
Prostaglandins for management of retained placenta (2014) · Cochrane
RR 0.8 [0.55, 1.15]2 studies · 194 participantsVery low
Intervention NR
Blood transfusion Blood transfusion during puerperium · women with retained placenta
Prostaglandins for management of retained placenta (2014) · Cochrane
RR 0.72 [0.43, 1.22]3 studies · 244 participantsVery low
Intervention NR
Mean blood loss Objectively or subjectively measured after intervention/Mean blood loss in ML. · women with retained placenta
Prostaglandins for management of retained placenta (2014) · Cochrane
no estimate extracted3 studies · 244 participantsVery low
Intervention NR
Mean time from injection to placenta removal Mean time from injection to placenta removal. · women with retained placenta
Prostaglandins for management of retained placenta (2014) · Cochrane
no estimate extracted1 study · 99 participantsVery low
Intervention NR
Maternal pain between injection and discharge from labour ward Maternal pain between injection and discharge from labour ward · women with retained placenta
Prostaglandins for management of retained placenta (2014) · Cochrane
RR 0.91 [0.43, 1.96]2 studies · 124 participantsVery low
Intervention NR
Nausea between injection and discharge from labour ward Nausea between injection and discharge from labour ward · women with retained placenta
Prostaglandins for management of retained placenta (2014) · Cochrane
RR 1.72 [0.15, 19.41]2 studies · 124 participantsVery low
Antibiotics vs antibiotics
Maternal death · women in labor with management of intra‐amniotic infection
Antibiotic regimens for management of intra‐amniotic infection (2014) · Cochrane
no estimate extracted1 study · 38 participantsUngraded
Antibiotics vs no treatment during postpartum period
Postpartum endometritis · women with management of intra‐amniotic infection
Antibiotic regimens for management of intra‐amniotic infection (2014) · Cochrane
RR 1.48 [0.68, 3.24]1 study · 116 participantsVery low
Antibiotics vs no treatment during postpartum period
Duration of maternal and neonatal hospital stay · women with management of intra‐amniotic infection
Antibiotic regimens for management of intra‐amniotic infection (2014) · Cochrane
no estimate extracted0 studies · 0 participantsUngraded
Antibiotics vs no treatment during postpartum period
Need for additional antibiotic therapy · women with management of intra‐amniotic infection
Antibiotic regimens for management of intra‐amniotic infection (2014) · Cochrane
no estimate extracted0 studies · 0 participantsUngraded
Antibiotics vs no treatment during postpartum period
Postpartum readmission for endometritis · women with management of intra‐amniotic infection
Antibiotic regimens for management of intra‐amniotic infection (2014) · Cochrane
no estimate extracted0 studies · 0 participantsUngraded
Antibiotics vs no treatment during postpartum period
Failure of treatment · women with management of intra‐amniotic infection
Antibiotic regimens for management of intra‐amniotic infection (2014) · Cochrane
no estimate extracted0 studies · 0 participantsUngraded
Antibiotics vs placebo during postpartum period
Maternal and neonatal mortality · women with management of intra‐amniotic infection
Antibiotic regimens for management of intra‐amniotic infection (2014) · Cochrane
no estimate extracted0 studies · 0 participantsUngraded
Antibiotics vs placebo during postpartum period
Maternal and neonatal severe infection · women with management of intra‐amniotic infection
Antibiotic regimens for management of intra‐amniotic infection (2014) · Cochrane
no estimate extracted0 studies · 0 participantsUngraded
Antibiotics vs placebo during postpartum period
Duration of maternal and neonatal hospital stay · women with management of intra‐amniotic infection
Antibiotic regimens for management of intra‐amniotic infection (2014) · Cochrane
no estimate extracted0 studies · 0 participantsUngraded
Antibiotics vs placebo during postpartum period
Endomyometritis · women with management of intra‐amniotic infection
Antibiotic regimens for management of intra‐amniotic infection (2014) · Cochrane
no estimate extracted2 studies · 288 participantsUngraded
Antibiotics vs placebo during postpartum period
Need for additional antibiotic therapy · women with management of intra‐amniotic infection
Antibiotic regimens for management of intra‐amniotic infection (2014) · Cochrane
no estimate extracted0 studies · 0 participantsUngraded
Antibiotics vs antibiotics
Neonatal deaths · women in labor with management of intra‐amniotic infection
Antibiotic regimens for management of intra‐amniotic infection (2014) · Cochrane
RR 1.39 [0.24, 8.06]1 study · 133 participantsVery low
Antibiotics vs placebo during postpartum period
Postpartum readmission for endometritis · women with management of intra‐amniotic infection
Antibiotic regimens for management of intra‐amniotic infection (2014) · Cochrane
no estimate extracted0 studies · 0 participantsUngraded
Antibiotics vs placebo during postpartum period
Treatment failure · women with management of intra‐amniotic infection
Antibiotic regimens for management of intra‐amniotic infection (2014) · Cochrane
RR 0.97 [0.14, 6.77]2 studies · 288 participantsVery low
Antibiotic vs antibiotics during postpartum period
Maternal and neonatal mortality · women with management of intra‐amniotic infection
Antibiotic regimens for management of intra‐amniotic infection (2014) · Cochrane
no estimate extracted0 studies · 0 participantsUngraded
Antibiotic vs antibiotics during postpartum period
Maternal and neonatal severe infection · women with management of intra‐amniotic infection
Antibiotic regimens for management of intra‐amniotic infection (2014) · Cochrane
no estimate extracted0 studies · 0 participantsUngraded
Antibiotic vs antibiotics during postpartum period
Length of treatment (days) · women with management of intra‐amniotic infection
Antibiotic regimens for management of intra‐amniotic infection (2014) · Cochrane
no estimate extracted1 study · 131 participantsVery low
Antibiotic vs antibiotics during postpartum period
Endometritis · women with management of intra‐amniotic infection
Antibiotic regimens for management of intra‐amniotic infection (2014) · Cochrane
no estimate extracted0 studies · 0 participantsUngraded
Antibiotic vs antibiotics during postpartum period
Postpartum readmission for endometritis · women with management of intra‐amniotic infection
Antibiotic regimens for management of intra‐amniotic infection (2014) · Cochrane
no estimate extracted0 studies · 0 participantsUngraded
Antibiotic vs antibiotics during postpartum period
Treatment failure · women with management of intra‐amniotic infection
Antibiotic regimens for management of intra‐amniotic infection (2014) · Cochrane
RR 1.02 [0.27, 3.89]1 study · 131 participantsVery low
Antibiotics (short duration) vs antibiotics (long duration) postpartum
Maternal and neonatal mortality · women with management of intra‐amniotic infection
Antibiotic regimens for management of intra‐amniotic infection (2014) · Cochrane
no estimate extracted0 studies · 0 participantsUngraded