Cochrane · systematic review · CD009708
Ambroxol for women at risk of preterm birth for preventing neonatal respiratory distress syndrome
Gonzalez Garay, AG, Reveiz, L, Velasco Hidalgo, L, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
Pregnancy and ChildbirthAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 12.5%Low 5 · 62.5%Moderate 2 · 25%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Ambroxol versus corticosteroid (betamethasone) for women at risk of preterm birth for preventing neonatal respiratory distress syndrome
Population: pregnant women at risk of preterm birth for preventing neonatal respiratory distress syndrome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Incidence of RDS frequency in newborns Ambroxol vs corticosteroid (betamethasone) | RR 0.79 [0.59, 1.07] | 7 studies · 758 participants | Moderate |
Perinatal mortality frequency of deaths of newborns Ambroxol vs corticosteroid (betamethasone) | RR 0.51 [0.23, 1.12] | 6 studies · 657 participants | Moderate |
Adverse effects in pregnant women frequency in pregnant women Ambroxol vs corticosteroid (betamethasone) | RR 3.45 [0.34, 35.51] | 3 studies · 305 participants | Very low Downgraded: inconsistency |
Ambroxol versus placebo or no treatment for women at risk of preterm birth for preventing neonatal respiratory distress syndrome
Population: pregnant women at risk of preterm birth for preventing neonatal respiratory distress syndrome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Incidence of RDS frequency in newborns Ambroxol vs placebo or no treatment | RR 0.74 [0.46, 1.2] | 2 studies · 204 participants | Low Downgraded: inconsistency |
Perinatal mortality frequency of deaths of newborns Ambroxol vs placebo or no treatment | RR 0.61 [0.19, 1.98] | 1 study · 116 participants | Low Downgraded: inconsistency |
Adverse effects in pregnant women frequency in pregnant women Ambroxol vs placebo or no treatment | RR 1.79 [0.45, 7.13] | 1 study · 116 participants | Low Downgraded: inconsistency |
Other events in newborns ‐ Administration of pulmonary surfactant frequency in newborns Ambroxol vs placebo or no treatment | RR 1.19 [0.61, 2.3] | 1 study · 88 participants | Low Downgraded: inconsistency |
Other events in newborns ‐ Need for mechanical ventilation frequency inf newborns Ambroxol vs placebo or no treatment | RR 0.94 [0.73, 1.21] | 1 study · 88 participants | Low Downgraded: inconsistency |