Serum 25-hydroxyvitamin D level · Preschool children ≤6 years, North America
In North America, children with S-ECC had lower serum 25(OH)D than caries-free children (WMD -13.28 nmol/l; ungraded).
1 finding from 1 review
Early childhood caries (ECC) · Children aged 6 years or younger (preschool children)
Serum 25(OH)D <50 nmol/l (vs 50–75 nmol/l) was associated with higher odds of ECC (OR 1.47; ungraded).
1 finding from 1 review
Rotation of the mandibular second permanent molar · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)
After mandibular first molar extraction, the second molar was rotated in about 77% of cases (2 studies; very imprecise; not GRADE-rated).
1 finding from 1 review
Serum 25-hydroxyvitamin D level · Children aged 6 years or younger (preschool children)
Children with severe ECC had significantly lower serum 25(OH)D than caries-free children (WMD -18.64 nmol/l; ungraded).
1 finding from 1 review
Early childhood caries (ECC) · Preschool children ≤6 years, North America
In North America, 25(OH)D 50–75 nmol/l (vs ≥75) was associated with higher odds of ECC (OR 2.09; ungraded).
1 finding from 1 review
High salivary S. mutans (over 10^4 CFU/ml) · Periodontitis patients
High-level S. mutans did not change significantly after periodontal therapy (OR 1.54).
1 finding from 1 review
Early childhood caries (ECC) · Preschool children ≤6 years, Asia and Europe
In Asia and Europe, 25(OH)D 50–75 nmol/l (vs ≥75) was associated with higher odds of ECC (OR 1.32; ungraded).
1 finding from 1 review
Moderate gingival inflammation / gingival health · Persons with disabilities (children and adults with autism, Down syndrome, cerebral palsy, hearing impairment, or multiple disabilities)…
Gingival inflammation is common among persons with disabilities in Saudi Arabia (moderate-to-severe up to about 60%), reported narratively without a pooled comparative estimate (ungraded).
1 finding from 1 review
Enamel demineralization (QLF ΔF) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
Flash-free brackets showed no clinical WSL reduction, with certainty not graded.
1 finding from 1 review
Serum 25-hydroxyvitamin D level · Children aged 6 years or younger (preschool children)
Preschool children with ECC had significantly lower serum 25(OH)D than caries-free children (WMD -13.96 nmol/l; ungraded).
1 finding from 1 review
Periodontal disease - novel loci (meta-analysis) · Adults from Japanese and European cohorts (present study + GLIDE + UK Biobank + BioBank Japan); periodontal disease cases vs controls
The meta-analysis found no novel loci for periodontal disease; the European SIGLEC5/chr19 locus did not replicate in Japanese populations; ungraded.
1 finding from 1 review
Genome-wide association meta-analysis identifies two novel loci associated with dental caries. 2024 All outcomesLifelong (germline genotype) · Population-based genetic association study (Japanese + European cohorts) · Meta-analysis: present study + GLIDE + UKB + BBJ
Meta-analysis of periodontal disease identified only previously known loci; no novel loci. The chromosome-19 SIGLEC5 locus associated with periodontitis in Europeans was not replicated in Japanese populations (present…
4 studies · 764572 participants
GRADE not reported
Number of paracetamol (acetaminophen) with codeine tablets required · Adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or systemic involvement)
Postoperative systemic antibiotics… showed no clear difference in number of paracetamol (acetaminophen) with codeine tablets required compared with matched placebo, partial or total chemo-mechanical debridement and…; GRADE not reported.
1 finding from 1 review
Incidence of new ICLs (proportion of subjects developing new lesions) · Patients undergoing fixed orthodontic treatment with fixed (multibracket) appliances, followed for development of new ICLs
About 48% of patients developed new ICLs during fixed orthodontic treatment (pooled incidence 0.48, 95% CI 0.33-0.63; very low certainty; very high heterogeneity).
1 finding from 1 review
Endodontic flare-up · Adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or systemic involvement)
Postoperative systemic antibiotics… showed no clear difference in endodontic flare-up compared with matched placebo, partial or total chemo-mechanical debridement and…; GRADE not reported.
1 finding from 1 review
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
Resin infiltration did not differ significantly from CPP-ACFP (SMD -0.52, 95% CI -1.16 to 0.12; indirect evidence only); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
P11-4 plus fluoride varnish was significantly better than CPP-ACP (SMD -0.78, 95% CI -1.33 to -0.24; indirect evidence only); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
Plaque · Orthodontic patients undergoing comprehensive treatment (late mixed or permanent dentition, no active caries)
In randomized trials, clear aligners probably reduce plaque accumulation versus fixed appliances, though the subgroup estimate is imprecise and its CI crosses no effect (SMD -1.79, 95% CI -3.63 to 0.04; moderate certainty).
6 findings from 1 review
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Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
Resin infiltration was significantly better than fluoride varnish (SMD -0.70, 95% CI -1.18 to -0.21); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
Resin infiltration and P11-4 plus fluoride varnish did not differ significantly (SMD 0.01, 95% CI -0.62 to 0.65; indirect evidence only); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
White spot lesion incidence · Orthodontic patients undergoing comprehensive treatment (late mixed or permanent dentition, no active caries)
Most studies reported a lower incidence of white spot lesions with clear aligners than fixed appliances, but heterogeneous assessment methods precluded meta-analysis (ungraded).
1 finding from 1 review