What do systematic reviews say?

Prophylactic platelet transfusion prior to surgery vs alternative treatment

The review found no eligible studies for this question.

• Prophylactic platelet transfusions prior to surgery for people with a low platelet count 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Prophylactic antibiotics vs placebo or no treatment

It is very uncertain whether prophylactic antibiotics (single or combined drugs) changes number of surgical site infections (SSIs) before discharge compared with placebo or no treatment (very low certainty).

• Prophylactic antibiotics for preventing infection after continence surgery in women with stress urinary incontinence 2022 · Cochrane Headline outcomes only
  RR 0.56 [0.13, 12.35]
  2 studies · 85 participants
  Very low

Prophylactic antibiotics vs placebo or no treatment

The review found no eligible studies for this question.

• Prophylactic antibiotics for preventing infection after continence surgery in women with stress urinary incontinence 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Prophylactic antibiotics vs placebo or no treatment

It is very uncertain whether prophylactic antibiotics (single or combined drugs) changes number of symptomatic UTIs or bacteriuria before discharge compared with placebo or no treatment (very low certainty).

• Prophylactic antibiotics for preventing infection after continence surgery in women with stress urinary incontinence 2022 · Cochrane Headline outcomes only
  RR 0.84 [0.05, 13.24]
  2 studies · 85 participants
  Very low

Prophylactic antibiotics vs placebo or no treatment

It is very uncertain whether prophylactic antibiotics (single or combined drugs) changes number of women with febrile morbidity at hospital discharge compared with placebo or no treatment (very low certainty).

• Prophylactic antibiotics for preventing infection after continence surgery in women with stress urinary incontinence 2022 · Cochrane Headline outcomes only
  RR 0.08 [0, 1.29]
  2 studies · 85 participants
  Very low

Prophylactic antibiotics vs placebo or no treatment

The review found no eligible studies for this question.

• Prophylactic antibiotics for preventing infection after continence surgery in women with stress urinary incontinence 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Prophylactic antibiotics vs placebo or no treatment

It is very uncertain whether prophylactic antibiotics (single or combined drugs) changes number of mesh exposures within six weeks after the operation compared with placebo or no treatment (very low certainty).

• Prophylactic antibiotics for preventing infection after continence surgery in women with stress urinary incontinence 2022 · Cochrane Headline outcomes only
  RR 0.32 [0.01, 7.61]
  1 study · 59 participants
  Very low

Prophylactic dopamine antagonist antiemetic medications vs placebo

Prophylactic dopamine antagonist antiemetic medications showed no clear difference in vomiting (≥1 episode) compared with placebo (low certainty).

• Prophylactic antiemetics for adults receiving intravenous opioids in the acute care setting 2022 · Cochrane Headline outcomes only
  RR 1.18 [0.26, 5.32]
  3 studies · 527 participants
  Low

Prophylactic dopamine antagonist antiemetic medications vs placebo

Prophylactic dopamine antagonist antiemetic medications showed no clear difference in nausea (≥1 episode) compared with placebo (low certainty).

• Prophylactic antiemetics for adults receiving intravenous opioids in the acute care setting 2022 · Cochrane Headline outcomes only
  RR 0.55 [0.15, 2.03]
  2 studies · 336 participants
  Low

Prophylactic dopamine antagonist antiemetic medications vs placebo

Prophylactic dopamine antagonist antiemetic medications showed no clear difference in adverse events compared with placebo (low certainty).

• Prophylactic antiemetics for adults receiving intravenous opioids in the acute care setting 2022 · Cochrane Headline outcomes only
  RR 2.34 [0.47, 11.61]
  3 studies · 527 participants
  Low

Prophylactic dopamine antagonist antiemetic medications vs placebo

The review found no eligible studies for this question.

• Prophylactic antiemetics for adults receiving intravenous opioids in the acute care setting 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Prophylactic dopamine antagonist antiemetic medications vs placebo

• Prophylactic antiemetics for adults receiving intravenous opioids in the acute care setting 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 191 participants
  Low

Prophylactic dopamine antagonist antiemetic medications vs placebo

Prophylactic dopamine antagonist antiemetic medications showed no clear difference in rescue medication compared with placebo (low certainty).

• Prophylactic antiemetics for adults receiving intravenous opioids in the acute care setting 2022 · Cochrane Headline outcomes only
  RR 1.86 [0.17, 20.16]
  3 studies · 527 participants
  Low

Prophylactic platelet transfusion at threshold of 10,000 vs higher transfusion threshold (20,000 or 30,000)

• Comparison of different platelet count thresholds to guide administration of prophylactic platelet transfusion for… 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 255 participants
  Low
• Prophylactic platelet transfusion for prevention of bleeding in patients with haematological disorders after… 2012 · Cochrane Headline outcomes only
  RR 1.72 [1.33, 2.22]
  2 studies · 94205 participants
  Moderate

Prophylactic platelet transfusion at threshold of 10,000 vs higher transfusion threshold (20,000 or 30,000)

• Comparison of different platelet count thresholds to guide administration of prophylactic platelet transfusion for… 2015 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 333 participants
  Low
• Prophylactic platelet transfusion for prevention of bleeding in patients with haematological disorders after… 2012 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 333 participants
  Moderate

Prophylactic platelet transfusion at threshold of 10,000 vs higher transfusion threshold (20,000 or 30,000)

Prophylactic platelet transfusion at threshold of 10,000 showed no clear difference in numbers of participants with at least 1 clinically significant… compared with higher transfusion threshold (20,000 or 30,000) (low certainty).

• Comparison of different platelet count thresholds to guide administration of prophylactic platelet transfusion for… 2015 · Cochrane Headline outcomes only
  RR 1.35 [0.95, 1.9]
  3 studies · 499 participants
  Low

Prophylactic platelet transfusion at threshold of 10,000 vs higher transfusion threshold (20,000 or 30,000)

Prophylactic platelet transfusion at threshold of 10,000 showed no clear difference in number of participants with WHO Grade 3 or 4 bleeding up to 30 days… compared with higher transfusion threshold (20,000 or 30,000) (low certainty).

• Comparison of different platelet count thresholds to guide administration of prophylactic platelet transfusion for… 2015 · Cochrane Headline outcomes only
  RR 0.99 [0.52, 1.88]
  2 studies · 421 participants
  Low

Prophylactic platelet transfusion at threshold of 10,000 vs higher transfusion threshold (20,000 or 30,000)

Prophylactic platelet transfusion at threshold of 10,000 showed no clear difference in time to first bleeding episode (days) compared with higher transfusion threshold (20,000 or 30,000) (low certainty).

• Comparison of different platelet count thresholds to guide administration of prophylactic platelet transfusion for… 2015 · Cochrane Headline outcomes only
  HR 1.11 [0.64, 1.91]
  1 study · 255 participants
  Low

Prophylactic platelet transfusion at threshold of 10,000 vs higher transfusion threshold (20,000 or 30,000)

Prophylactic platelet transfusion at threshold of 10,000 showed no clear difference in mortality from all causes up to 30 days from study entry compared with higher transfusion threshold (20,000 or 30,000) (low certainty).

• Comparison of different platelet count thresholds to guide administration of prophylactic platelet transfusion for… 2015 · Cochrane Headline outcomes only
  RR 1.78 [0.83, 3.81]
  1 study · 255 participants
  Low

Prophylactic platelet transfusion at threshold of 10,000 vs higher transfusion threshold (20,000 or 30,000)

The review found no eligible studies for this question.

• Comparison of different platelet count thresholds to guide administration of prophylactic platelet transfusion for… 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found