Cochrane · systematic review · CD010983
Comparison of different platelet count thresholds to guide administration of prophylactic platelet transfusion for preventing bleeding in people with haematological disorders after myelosuppressive chemotherapy or stem cell transplantation
Estcourt, LJ, Stanworth, SJ, Doree, C, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
HaematologyAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
6
No studies
1
Included studies
NR
No studies 1 · 14.3%Ungraded 0 · 0%Very low 0 · 0%Low 6 · 85.7%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Prophylactic platelet transfusion at threshold of 10,000 compared to higher transfusion threshold (20,000 or 30,000) for people with a haematological disorder
Population: People with a haematological disorder
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Numbers of participants with at least 1 clinically significant bleeding event up to 30 days from study entry Prophylactic platelet transfusion at threshold of 10,000 vs higher transfusion threshold (20,000 or 30,000) | RR 1.35 [0.95, 1.9] | 3 studies · 499 participants | Low Downgraded: imprecision |
Number of days on which clinically significant bleeding occurred per participant up to 30 days from study entry Prophylactic platelet transfusion at threshold of 10,000 vs higher transfusion threshold (20,000 or 30,000) | no estimate extracted | 1 study · 255 participants | Low Downgraded: imprecision |
Number of participants with WHO Grade 3 or 4 bleeding up to 30 days from study entry Prophylactic platelet transfusion at threshold of 10,000 vs higher transfusion threshold (20,000 or 30,000) | RR 0.99 [0.52, 1.88] | 2 studies · 421 participants | Low Downgraded: imprecision |
Time to first bleeding episode (days) Prophylactic platelet transfusion at threshold of 10,000 vs higher transfusion threshold (20,000 or 30,000) | HR 1.11 [0.64, 1.91] | 1 study · 255 participants | Low Downgraded: imprecision |
Number of platelet transfusions per participant up to 30 days from study entry Prophylactic platelet transfusion at threshold of 10,000 vs higher transfusion threshold (20,000 or 30,000) | no estimate extracted | 2 studies · 333 participants | Low Downgraded: imprecision |
Mortality from all causes up to 30 days from study entry Prophylactic platelet transfusion at threshold of 10,000 vs higher transfusion threshold (20,000 or 30,000) | RR 1.78 [0.83, 3.81] | 1 study · 255 participants | Low Downgraded: imprecision |
Quality of life ‐ not reported Prophylactic platelet transfusion at threshold of 10,000 vs higher transfusion threshold (20,000 or 30,000) | no estimate extracted | NR | No studies |