Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,692 questions · 2,586 findings · 180 reviews · Dental caries

No studies found 194 · 7.5%GRADE not reported 1,937 · 74.9%Very low 248 · 9.6%Low 136 · 5.3%Moderate 52 · 2%High 19 · 0.7%

Prophylaxis (teeth cleaning) and CHX or iodine-NaF solution application in the dentition of women (mothers) vs placebo

Child microbiological presence (mutans streptococci acquisition) · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age
1 finding from 1 review

Dietary advice on how to achieve a healthy diet for infants (tailored advice focused on a diet low in saturated fat and cholesterol intake) vs usual care

Caries presence in primary teeth · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…

It is very uncertain whether dietary advice on how to achieve a healthy diet for infants… changes caries presence in primary teeth compared with standard care (very low certainty).

1 finding from 1 review

Dental caries assessment (WHO/clinical diagnostic criteria; caries = DMFT>0) vs None (descriptive prevalence review; subgroup analyses by urban/rural status, country and year)

Dental caries prevalence · 12-year-old children (permanent dentition) in Africa

Pooled caries prevalence in Uganda was 0.27 (95% CI 0.126 to 0.418; 3 article(s); not GRADE-rated).

23 findings from 1 review
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Cesarean section delivery vs Vaginal delivery

Caries prevalence (early childhood caries) · Toddlers and preschool children, 2 to 6 years of age (primary dentition)

Caesarean section delivery may be associated with a modestly higher prevalence of early childhood caries than vaginal delivery (pooled OR 1.48), but the evidence is inconsistent and of very low certainty.

1 finding from 1 review

Fluoride gel (topically applied; operator- or self-applied; any fluoride agent/concentration; frequency at least once a year) vs placebo or no treatment

Caries increment in primary/deciduous teeth: decayed, (extraction indicated/missing) and filled teeth d(e/m)ft (prevented fraction) · Children with primary (deciduous) teeth (younger children)

The review found no eligible studies for this question.

1 finding from 1 review

Dental crowding present vs Dental spacing present

Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)

One study found space closure more likely with crowding than spacing (OR 5.9; single study; not GRADE-rated).

1 finding from 1 review

Polyether impression material vs Polyvinyl siloxane impression material

Pulp necrosis · Vital teeth

The pooled incidence with polyether impression material was 4.02%.

2 findings from 1 review

Pre-operative bone level < 35% vs Pre-operative bone level ≥ 35%

Periapical pathosis incidence · Vital teeth

One study reported a 1.4% incidence with bone level < 35%.

2 findings from 1 review

Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability

Lumbar spine and pelvis fracture · European GWAS participants

The SVMR Weighted Median interval included the null.

3 findings from 1 review

Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability

Osteoporosis · European GWAS participants

The SVMR MR-Egger interval included the null.

4 findings from 1 review
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Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability

Osteoporosis with pathological fracture · European GWAS participants

The SVMR Weighted Median interval included the null.

3 findings from 1 review

Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability

Forearm fracture · European GWAS participants

The SVMR Weighted Median interval included the null.

3 findings from 1 review

Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability

Osteoporosis with pathological fracture · European-ancestry adults

Genetically predicted periodontitis had no causal effect on osteoporosis with pathological fracture (single-variable MR, OR 1.003).

2 findings from 1 review

Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability

Lumbar spine and pelvis fracture · European-ancestry adults

Genetically predicted periodontitis had no causal effect on fracture of lumbar spine and pelvis (multivariable MR, OR 1.060).

2 findings from 1 review

Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability

Femoral neck bone mineral density (FN-BMD) · European-ancestry adults

Genetically predicted periodontitis had no causal effect on femoral neck BMD.

1 finding from 1 review