Caries arrestment at the tooth level · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition)
Pooling two trials, SDF and nano-silver fluoride showed no significant difference in tooth-level caries arrestment (OR 1.47; ungraded subgroup).
1 finding from 1 review
Number of detected salivary bacterial genera · Young children with early childhood caries and caries-free controls
Fewer salivary bacterial genera were reported in the caries-affected group, without a comparative effect estimate or CI.
1 finding from 1 review
Relative abundance of dominant salivary microbial community (7 genera) · Young children with early childhood caries and caries-free controls
The reported multi-genus community had similar relative abundance in caries-affected and caries-free children, without a comparative effect estimate or CI.
1 finding from 1 review
Streptococcus mutans and Veillonella spp. levels · Young children with early childhood caries and caries-free controls
Veillonella spp. levels were reported as substantially greater in caries subjects, but the review gave no numerical effect estimate or CI.
1 finding from 1 review
Oral disease outcomes, including dental caries estimates · People of all ages and abilities served through primary care and related settings (children, pregnant women, older adults in…
Most studies reported improved oral disease outcomes with integration strategies (8 of 9 studies improved, 1 no change; 9 studies, narrative synthesis; ungraded).
1 finding from 1 review
Dental caries · Children with permanent dentition (>12 years)
In children with permanent dentition, vitamin D deficiency was associated with a 28% higher caries risk (RR 1.28; ungraded).
1 finding from 1 review
RR 1.28 [1.21, 1.35]
2 studies
GRADE not reported
Dental caries · Children with deciduous dentition (<6 years)
In children with deciduous dentition, vitamin D deficiency was associated with a 68% higher caries risk (RR 1.68; ungraded).
1 finding from 1 review
RR 1.68 [1.57, 1.79]
6 studies
GRADE not reported
Dental caries · Children (mixed dentition; baseline about 8 years)
In children with mixed dentition, vitamin D deficiency was associated with an 8% higher caries risk (RR 1.08; ungraded).
1 finding from 1 review
RR 1.08 [1.04, 1.12]
4 studies
GRADE not reported
Relative abundance of Veillonella spp. · Children under 6 years with severe early childhood caries and caries-free controls
Veillonella spp. mean relative abundance was lower in the S-ECC group; no comparative effect estimate or CI was reported.
1 finding from 1 review
Relative abundance of S. mutans in saliva · Children under 6 years with severe early childhood caries and caries-free controls
S. mutans median relative abundance was higher in the S-ECC group, without a comparative effect estimate or CI.
1 finding from 1 review
Streptococcus relative abundance · Children under 6 years with severe early childhood caries and caries-free controls
Streptococcus mean relative abundance was slightly higher in the S-ECC group; no comparative effect estimate or CI was reported.
1 finding from 1 review
Veillonella spp. and Streptococcus mutans interaction · Children under 6 years with severe early childhood caries and caries-free controls
The study reported a possible role for Veillonella spp. in supporting cariogenic species, without a quantitative effect estimate.
1 finding from 1 review
Veillonella spp. may promote proliferation or survival of cariogenic species, as shown for interactions between Veillonella spp. and S. mutans.
1 study · 82 participants
GRADE not reported
Veillonella dispar relative abundance · Children under 6 years with severe early childhood caries and caries-free controls
Veillonella dispar median relative abundance was higher in the S-ECC group, without a comparative effect estimate or CI.
1 finding from 1 review
Dental caries · Children aged 2 to 8 years
The review reported a lower odds ratio at maternal prenatal vitamin D ≤50 nmol/L than at ≤35 nmol/L, without a numeric value in the available sources.
1 finding from 1 review
Dental caries prevalence · Children aged 2 to 8 years
The review reported 44% dental caries prevalence among children of mothers with low prenatal vitamin D.
2 findings from 1 review
Dental caries · Children aged 2 to 8 years
The review reported an OR of 1.32 when prenatal vitamin D was measured at 6 to 38 gestational weeks.
2 findings from 1 review
Dental caries · Children aged 2 to 8 years
The review reported a slightly higher odds ratio at maternal prenatal vitamin D ≤35 nmol/L than at ≤50 nmol/L, without a numeric value in the available sources.
1 finding from 1 review
Dental caries prevalence · Children with beta-thalassemia major in Dubai
Dental caries prevalence was 68.4% in children with beta-thalassemia major versus 48.7% in controls.
1 finding from 1 review
Prevalence 68.4
1 study
GRADE not reported
new carious lesions or fillings · Children with dental caries in permanent (first) molars
The review reported no significant result for SDF; no effect estimate or GRADE rating was reported.
1 finding from 1 review
Streptococcus mutans acid (lactic acid) production and cariogenic potential · Oral biofilm of children/individuals at risk of dental caries
The review concludes that Veillonella spp. may modulate (often inhibit) S. mutans acid production and compete for lactate substrate, potentially reducing cariogenesis, but the evidence is narrative and ungraded.
1 finding from 1 review