Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

401 questions · 403 findings · 75 reviews · Headline outcomes only

No studies found 79 · 19.6%GRADE not reported 18 · 4.5%Very low 91 · 22.6%Low 110 · 27.3%Moderate 79 · 19.6%High 26 · 6.5%

Continuous chest compression alone vs interrupted chest compression plus artificial ventilation

Neurological function at hospital discharge, measured by cerebral performance category (CPC) · Patients with non‐trauma related out‐of‐hospital cardiac arrest

Continuous chest compression alone showed no clear difference in neurological outcomes at hospital discharge Measured as 'good' or… compared with interrupted chest compression plus artificial ventilation (moderate certainty).

1 finding from 1 review

TACE followed by 3‐DCRT vs chemoembolisation

Proportion of participants without tumour response (CR+PR) · primary hepatocellular carcinoma

TACE followed by 3‐DCRT may leads to lower proportion of participants without tumour response (CR+PR) compared with TACE (low certainty).

1 finding from 1 review

TACE followed by 3‐DCRT vs chemoembolisation

Proportion of participants without serum AFP normalisation · primary hepatocellular carcinoma

It is very uncertain whether TACE followed by 3‐DCRT changes proportion of participants without serum AFP normalisation compared with TACE (very low certainty).

1 finding from 1 review

External beam radiotherapy (EBRT) plus transarterial chemoembolisation (TACE) vs TACE alone

Mortality Number of deaths at maximum · participants with unresectable hepatocellular carcinoma

External beam radiotherapy (EBRT) plus transarterial… may leads to lower all‐cause mortality (at maximum 1‐year compared with TACE alone (low certainty).

1 finding from 1 review

External beam radiotherapy (EBRT) plus transarterial chemoembolisation (TACE) vs TACE alone

Elevated alanine aminotransferase Length of · participants with unresectable hepatocellular carcinoma

It is very uncertain whether external beam radiotherapy (EBRT) plus transarterial… changes elevated alanine aminotransferase Length of compared with TACE alone (very low certainty).

1 finding from 1 review

External beam radiotherapy (EBRT) plus transarterial chemoembolisation (TACE) vs TACE alone

Elevated total bilirubin Length of · participants with unresectable hepatocellular carcinoma

It is very uncertain whether external beam radiotherapy (EBRT) plus transarterial… changes elevated total bilirubin Length of compared with TACE alone (very low certainty).

1 finding from 1 review

TG4010 added to chemotherapy vs chemotherapy alone

Adverse effects: at least one serious adverse event · People with advanced non‐small cell lung cancer

It is very uncertain whether TG4010 added to chemotherapy changes participants with at least one serious adverse event compared with chemotherapy alone (very low certainty).

1 finding from 1 review

Summary of findings ‐ triple therapy: elexacaftor‐tezacaftor‐ivacaftor vs control (ivacaftor alone or tezacaftor plus ivacaftor)

Adverse events ‐ treatment emergent · adults and children aged 12 years and over with cystic fibrosis and either F508del/gating variant or F508del/residual function genotype

Summary of findings ‐ triple therapy: elexacaftor‐tezacaftor‐ivacaftor showed no clear difference in adverse events: number of participants with treatment‐emergent… compared with control (ivacaftor alone or tezacaftor plus ivacaftor) (moderate certainty).

1 finding from 1 review