Cochrane · systematic review · CD000528
Drugs for treating Schistosoma mansoni infection
Danso‐Appiah, A, Olliaro, PL, Donegan, S, et al. · Cochrane Database of Systematic Reviews · 2013 · Cochrane Library
Infectious DiseasesAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
4
current version
GRADE rated
4
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 50%Low 0 · 0%Moderate 2 · 50%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Praziquantel 40 mg/kg for treating S. mansoni infection
Population: People with S. mansoni infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Parasitological failure at 1 month | RR 3.13 [1.03, 9.53] | 2 studies · 414 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Oxamniquine 40 mg/kg for treating S. mansoni infection
Population: People with S. mansoni infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Parasitological failure at 1 month | RR 8.74 [3.74, 20.43] | 2 studies · 82 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |
Oxamniquine 40 mg/kg versus praziquantel 40 mg/kg
Population: People with S. mansoni infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Parasitological failure at 1 month Oxamniquine 40 mg/kg vs praziquantel 40 mg/kg | RR 0.4 [0.13, 1.22] | 1 study · 33 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Artesunate (12 mg/kg) plus praziquantel (40 mg/kg) versus praziquantel (40 mg/kg) alone
Population: People with S. mansoni infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Parasitological failure at 1 month Artesunate (12 mg/kg) plus praziquantel (40 mg/kg) vs praziquantel (40 mg/kg) alone | RR 0.62 [0.35, 1.09] | 1 study · 75 participants | Very low Downgraded: risk of bias, imprecision, indirectness |