Parotid hypertrophy prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
Parotid hypertrophy was significantly more prevalent in treatment-naive CLWH than in those on ART (very low certainty).
1 finding from 1 review
OR 0.01 [0.00, 0.05]
Studies not reported
Very low
Overweight/obesity risk · Healthy, term-born, normal-birth-weight infants aged 4-24 months (breastfed and/or formula-fed) in Western industrialized countries
Among observational studies, baby-led weaning was associated with lower odds of overweight/obesity than other feeding models (OR 0.37, 95% CI 0.25 to 0.55), but certainty is very low.
1 finding from 1 review
Dental caries · Children (deciduous and/or permanent dentition) in low- and middle-income countries
Good brushing habits (>=2 daily) were associated with 35% lower odds of dental caries (OR 0.65, 95% CI 0.46 to 0.92; 7 studies; not GRADE-rated).
1 finding from 1 review
Restoration failure · Children (2-9 years) with caries in posterior primary teeth
Single-surface ART restorations had a low reported mean annual failure rate (about 5%; ungraded).
1 finding from 1 review
Oral health-related quality of life · Children with dental caries
The direct estimate found no statistically significant difference in oral health-related quality of life between placebo and silver diamine fluoride.
2 findings from 1 review
Dental development and maturation · Children and adolescents (<18 years) living with HIV (CLWH)
A single small study suggested delayed dental development in CLWH on ART, but the evidence was insufficient to draw conclusions (very low certainty).
1 finding from 1 review
Dental caries (association with secondary/higher maternal education) · Children (deciduous and/or permanent dentition) in low- and middle-income countries
Secondary/higher maternal education showed no significant association with dental caries (OR 0.96, 95% CI 0.64 to 1.44; 7 studies; not GRADE-rated).
1 finding from 1 review
Caries experience (mean DMFT) · Children aged 12 years (plus or minus one year) in Africa
The pooled mean DMFT score was 1.0900 (95% CI 0.9143 to 1.2657); GRADE was not reported.
2 findings from 1 review
Mean DMFT 1.0900 [0.9143, 1.2657]
Studies not reported
GRADE not reported
Mean DMFT 1.1444 [0.9780, 1.3108]
Studies not reported
GRADE not reported
Contribution to total daily fluoride intake · children
For children in low-fluoridated areas, the mean contribution was 39% (SD 24%).
1 finding from 1 review
Infant weight-length gain (achievement of adequate weight) · Healthy, term-born, normal-birth-weight infants aged 4-24 months (breastfed and/or formula-fed) in Western industrialized countries
Baby-led weaning/BLISS did not significantly influence infant weight-length (adequate weight) gain versus other complementary feeding models (pooled OR 1.36, 95% CI 0.18 to 10.51; ungraded).
1 finding from 1 review
Oral hygiene · Children and adolescents (<18 years) living with HIV (CLWH)
Oral hygiene status did not differ significantly between CLWH with and without ART (very low certainty).
1 finding from 1 review
OR 0.73 [0.13, 4.26]
0 studies
GRADE not reported
Intervention not reported
Oral Candida carriage and salivary yeast concentration
1 finding from 1 review
no estimate extracted
1 study
GRADE not reported
Early childhood caries (ECC) - association at lead SNP rs76823412 (8:134690570; nearest gene(s) ST3GAL1) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
The common variant rs8091366 near CHST9, KCTD1 showed suggestive (not genome-wide significant) association with ECC (Z = 4.476, p = 7.60e-6); genetic association, ungraded.
2 findings from 1 review
Oral health-related quality of life · Children with dental caries
SDF did not significantly differ from placebo for oral health-related quality of life in children (MD 0.03, 95% CI -0.16 to 0.22; ungraded).
1 finding from 1 review
Dental caries · Children and adolescents (general population, aged under 20 years)
Evidence on food marketing and dental caries is very uncertain (very low certainty); 1 of 2 studies found an association.
1 finding from 1 review
Restoration failure · Children with carious primary teeth
No comparative effect estimate was reported; failure rates were tabulated.
1 finding from 1 review
Restoration failure · Children with carious primary teeth
No comparative effect estimate was reported; cumulative failure rates were tabulated.
1 finding from 1 review
Caries experience at the surface level (dmfs/defs) · Children (mean age newborn to ~5.2 years) and their parents/carers
Oral-health-education-only interventions did not show a statistically significant effect on surface-level caries (dmfs SMD -0.20, 95% CI -0.43 to 0.03; 2 studies; not GRADE-rated).
1 finding from 1 review
Angular cheilitis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No eligible studies compared angular cheilitis between different ART regimens.
1 finding from 1 review
Restoration failure · Children (3-13 years) with dentine caries in primary teeth, no pulpal involvement
ART with GIC was reported to increase the odds of restoration failure versus conventional restoration (OR 1.60; ungraded).
1 finding from 1 review