Proper surface staining · Children receiving dental restorations (aged 4-11 years; primary teeth; Class I/II/V cavities)
No significant difference between IRR and CR in surface staining (moderate certainty; downgraded for inconsistency).
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Adults aged 18 years or older with mature permanent teeth and carious pulp exposure
Tri-calcium silicate use was associated with a 37% increase in partial-pulpotomy success in meta-regression.
1 finding from 1 review
Early childhood caries (ECC) · Children aged 0-5 years in North Africa
Nighttime sugary food intake was associated with higher odds of ECC (OR 1.104; source CI garbled).
1 finding from 1 review
OR 1.104 [1.167, 2.826]
1 study
GRADE not reported
Oral health-related quality of life · people aged 60 years and older living in the community
Lower country-level dental caries prevalence was associated with better OHRQoL (low-prevalence pooled mean 81.5, 95% CI 76.5 to 86.6, higher than high-prevalence countries); statistically significant (ungraded).
1 finding from 1 review
MEAN 81.5 [76.5, 86.6]
Studies not reported
GRADE not reported
Negative oral-health impact on daily performance (OIDP or Child-OIDP) · Adolescents (10-19 years)
For experience (history) of dental caries, adolescents had a significantly worse oral-health impact: PR 1.72 (95% CI 1.23 to 2.43) from 6 studies (I2=97%); ungraded, and not statistically different from the presence subgroup (p=0.19).
1 finding from 1 review
Impact of dental caries on the quality of life of adolescents: A systematic review and meta-analysis. 2025 All outcomesCross-sectional (concurrent exposure and outcome); oral impacts recalled over the prior 6 months · School-based (17/20 studies), plus household and secondary-data surveys; low-, middle- and high-income countries (Brazil, Thailand, Tanzania, Saudi Arabia, Sri Lanka, Zambia, Iran, Serbia, Nepal, India, South Africa, China) · Caries-definition subgroup: experience of dental caries
PR 1.72 [1.23, 2.43]
6 studies
GRADE not reported
Oral health-related quality of life · people aged 60 years and older living in the community
The review reported higher OHRQoL in the low than high dental-caries-prevalence category.
1 finding from 1 review
71.40 [64.16, 78.63]
Studies not reported
GRADE not reported
Salivary immunoglobulin A and pH · children aged 6 to 12 years
No meta-analysis was conducted; postbiotic toothpaste was reported to increase salivary immunoglobulin A and pH versus fluoride toothpaste.
1 finding from 1 review
no estimate extracted
1 study
GRADE not reported
Early childhood caries (ECC) · Children aged 0-5 years in North Africa
Having one sibling was associated with higher odds of ECC (OR 3.32).
1 finding from 1 review
OR 3.32 [1.15, 9.54]
1 study
GRADE not reported
Adequate periodontal tissue · Children receiving dental restorations (aged 4-11 years; primary teeth; Class I/II/V cavities)
Uncertain whether IRR and CR differ in periodontal tissue outcomes (low certainty; downgraded for very serious inconsistency).
1 finding from 1 review
Dental caries · Children aged 2 to 8 years
The review reported a lower odds ratio at maternal prenatal vitamin D ≤50 nmol/L than at ≤35 nmol/L, without a numeric value in the available sources.
1 finding from 1 review
Dental caries · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…
The review found no eligible studies for this question.
2 findings from 1 review
Early childhood caries (ECC) · Preschool children (<6 years)
After excluding one study, nocturnal breastfeeding was associated with higher ECC risk (RR 3.05, 95% CI 2.40 to 3.87; I²=33%).
1 finding from 1 review
Perceived need for surgery in adulthood · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
The review found no eligible studies for this question.
1 finding from 1 review
Mother microbiological presence (high-level mutans streptococci / lactobacilli) · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age
Oral health education/promotion (oral hygiene advice plus diet and… showed no clear difference in mother microbiological presence (high-level mutans streptococci /… compared with standard care; GRADE not reported.
1 finding from 1 review
Caries presence in primary teeth · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age
It is very uncertain whether consumption of xylitol chewing gum by women (mothers) changes caries presence in primary teeth compared with consumption of CHX/xylitol gum by women, or CHX varnish applied to… (very low certainty).
1 finding from 1 review
Overjet · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
Bone-anchored intermaxillary traction (BAIMT) led to higher overjet compared with removable mandibular retractor (RMR); GRADE not reported.
1 finding from 1 review
Early childhood caries (ECC) · Children aged <6 years
No significant association between cesarean vs vaginal delivery and ECC among America/Canada/Brazil studies (OR 1.11, 95% CI 0.70-1.76).
17 findings from 1 review
OR 1.11 [0.70, 1.76]
5 studies
GRADE not reported
OR 0.86 [0.54, 1.38]
11 studies
GRADE not reported
OR 0.93 [0.65, 1.33]
12 studies
GRADE not reported
Show 14 more findings
Wits appraisal · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
Orthodontic removable traction appliance (ORTA) led to higher wits appraisal compared with untreated control (no treatment); GRADE not reported.
1 finding from 1 review
Mother microbiological presence · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age
1 finding from 1 review
Wits appraisal · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
Facemask (with frame internal fixation) showed no clear difference in wits appraisal compared with frankel III functional appliance; GRADE not reported.
1 finding from 1 review