Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

705 questions · 723 findings · 78 reviews

No studies found 198 · 27.4%GRADE not reported 30 · 4.1%Very low 158 · 21.9%Low 211 · 29.2%Moderate 98 · 13.6%High 28 · 3.9%

Topical disinfectants vs standard care or other active treatment (antibiotic or other disinfectant)

Catheter removal or replacement · chronic peritoneal dialysis patients

Topical disinfectants showed no clear difference in catheter removal or replacement (number of patients) compared with standard care or other active treatment (antibiotic or other… (low certainty).

1 finding from 1 review

Summary of findings: urate oxidase vs allopurinol

Organ system failure ‐ Renal insufficiency leading to replacement therapy · children with haematological malignancy at risk of tumour lysis syndrome

It is very uncertain whether summary of findings: urate oxidase changes renal failure requiring renal replacement therapy ( compared with allopurinol (very low certainty).

1 finding from 1 review

Statins vs placebo

Freedom from valve replacement · patients with aortic valve stenosis

Statin showed no clear difference in freedom from valve replacement compared with placebo (moderate certainty).

1 finding from 1 review

Intervention not reported

Number of smokers receiving nicotine gum/replacement therapy self‐report · Smokers treated by health professionals

The intervention showed no clear difference in number of smokers receiving nicotine gum/replacement therapy… (low certainty).

1 finding from 1 review

Resorbable (bioresorbable) plates or screws for fixation vs Titanium plates or screws for fixation

Need for retreatment or replacement of fixation due to failure of the fixation · Adults over 18 years of age with fractures of the facial skeleton including the mandible, maxilla, zygoma (malar); studies on fractures of…

The review found no eligible studies for this question.

1 finding from 1 review
  • Resorbable versus titanium plates for facial fractures 2009 · Cochrane All outcomes
    Up to 3 years postoperatively
    Planned primary outcome not assessed: none of the retrieved studies met the inclusion criteria, so no data were available for analysis. Verbatim (Effects of interventions): "Although 53 studies were retrieved in our…
    0 studies
    No studies found

Resin-modified glass ionomer (Vitremer) vs Amalgam restoration

Replacement (failure) of Class II restoration at 12 months · Children aged 12 years or younger with tooth decay involving at least one tooth in the primary dentition, symptomatic or symptom free

Resin-modified glass ionomer (Vitremer) showed no clear difference in replacement (failure) of Class II restoration at 12 months compared with amalgam; GRADE not reported.

1 finding from 1 review