Question · asked by 1 review

Summary of findings: high‐dose urate oxidase vs low‐dose urate oxidase: Organ system failure ‐ Renal insufficiency leading to replacement therapy

What each review found

Include earlier review versions
FindingEffectStudiesGRADE certainty
Summary of findings: high‐dose urate oxidase vs low‐dose urate oxidase
Renal failure requiring renal replacement therapy · children with haematological malignancy at risk of tumour lysis syndrome
Urate oxidase for the prevention and treatment of tumour lysis syndrome in children with cancer (2017) · Cochrane Headline outcomes only
no estimate extracted1 study · 29 participantsLow

Findings are shown side by side, never pooled across reviews.

The reviews

ReviewSearched up toIncluded studiesAMSTAR 2
Urate oxidase for the prevention and treatment of tumour lysis syndrome in children with cancer
2017 · Cochrane Headline outcomes only
Not reportedlist not extracted yetNot assessed

Studies behind the findings

None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.

How reviews are matched to this question

Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.