Cochrane · systematic review · CD009571
Statins for aortic valve stenosis
Thiago, L, Tsuji, SR, Nyong, J, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
HeartAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 14.3%Low 4 · 57.1%Moderate 2 · 28.6%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Statin versus Placebo for aortic valve stenosis
Population: patients with aortic valve stenosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mean pressure gradient (mmHg) Better indicated by lower scores. Statin vs Placebo | no estimate extracted | 2 studies · 1935 participants | Low Downgraded: risk of bias, imprecision, publication bias |
Valve area (cm2) Better indicated by higher scores. Statin vs Placebo | no estimate extracted | 2 studies · 127 participants | Low Downgraded: imprecision, publication bias |
Aortic jet velocity (m/s) Statin vs Placebo | no estimate extracted | 1 study · 155 participants | Low Downgraded: imprecision, publication bias |
Freedom from valve replacement Statin vs Placebo | RR 0.93 [0.81, 1.06] | 4 studies · 2360 participants | Moderate Downgraded: imprecision, publication bias |
Death from cardiovascular cause Statin vs Placebo | RR 0.8 [0.56, 1.15] | 3 studies · 2297 participants | Low Downgraded: imprecision, publication bias |
Hospitalisation for any reason Statin vs Placebo | RR 0.84 [0.39, 1.84] | 1 study · 155 participants | Very low Downgraded: imprecision, publication bias |
Adverse events ‐ Muscle pain Statin vs Placebo | RR 0.91 [0.75, 1.09] | 3 studies · 2204 participants | Moderate Downgraded: imprecision, publication bias |