Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

375 questions · 390 findings · 22 reviews · Pain, Palliative and Supportive Care

No studies found 117 · 30%GRADE not reported 36 · 9.2%Very low 111 · 28.5%Low 75 · 19.2%Moderate 48 · 12.3%High 3 · 0.8%

Acupuncture vs sham

Adverse effects (drop‐outs due to adverse effects4) · people with episodic migraine

Acupuncture showed no clear difference in number of participants dropping out due to adverse effects compared with sham interventions (low certainty).

1 finding from 1 review

Breastfeeding vs other interventions, oral water, or no treatment

All pain scores during injection Due to range of pain scores used, data analysed using SMDs. Pain scores were measured during and up to 3 minutes following completion of vaccination. · Infants 1 to 12 months during vaccination
2 findings from 1 review

SSRIs or SNRIs vs amitriptyline

Participants who withdraw because of an adverse event or any other reason · patients for whom migraine preventive interventions are indicated

SSRIs or SNRIs showed no clear difference in withdrawn (for any reasons and due to adverse events) compared with amitriptyline (low certainty).

1 finding from 1 review