Findings

What do systematic reviews say?

3,018 questions · 3,100 findings · 369 reviews · Headline outcomes only

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No studies found 774 · 25%GRADE not reported 108 · 3.5%Very low 727 · 23.5%Low 840 · 27.1%Moderate 474 · 15.3%High 177 · 5.7%

Minoxidil 2% vs minoxidil 5%

Degree of hair shedding from baseline to the end of the study · women with FPHL

1 finding from 1 review

Interventions for female pattern hair loss 2016 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Minoxidil 2% vs minoxidil 5%

Cosmetic appearance of the hair or participant satisfaction · women with FPHL

1 finding from 1 review

Interventions for female pattern hair loss 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 322 participants
Moderate

Minoxidil 2% vs minoxidil 5%

Change in quality (or pattern) of hair regrowth (e.g. thickness) · women with FPHL

1 finding from 1 review

Interventions for female pattern hair loss 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 322 participants
Moderate

Minoxidil 2% vs minoxidil 5%

Proportion of participants with self‐rated clinically significant hair regrowth · women with FPHL

1 finding from 1 review

Interventions for female pattern hair loss 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 322 participants
Low

Antibiotics vs placebo

Minor adverse events in sexual partner · sexual partners of women with bacterial vaginosis

Any antibiotic treatment may leads to higher minor adverse events in sexual partner compared with placebo (low certainty).

1 finding from 1 review

Antibiotic treatment for the sexual partners of women with bacterial vaginosis 2016 · Cochrane Headline outcomes only
RR 2.55 [1.55, 4.18]
3 studies · 477 participants
Low

Laser photocoagulation vs control

Progression of retinopathy · people with diabetic retinopathy

Laser photocoagulation may leads to lower progression of diabetic retinopathy compared with control (low certainty).

1 finding from 1 review

Laser photocoagulation for proliferative diabetic retinopathy 2014 · Cochrane Headline outcomes only
RR 0.49 [0.37, 0.64]
4 studies · 8331 participants
Low

Milrinone vs dobutamine

All‐cause mortality · adults with low cardiac output syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Inotropic agents and vasodilator strategies for the treatment of cardiogenic shock or low cardiac output syndrome 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical quinolone vs quinolones

Resolution of ear discharge ‐ measured at 1 to 2 weeks · people (of any age) with CSOM

Topical quinolone may leads to higher resolution of ear discharge ‐ 1 to 2 weeks compared with oral quinolone (low certainty).

1 finding from 1 review

Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
RR 1.48 [1.24, 1.76]
3 studies · 285 participants
Low

Topical quinolone vs quinolones

Resolution of ear discharge ‐ measured after 4 weeks · people (of any age) with CSOM

The review found no eligible studies for this question.

1 finding from 1 review

Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical quinolone vs quinolones

Health‐related quality of life · people (of any age) with CSOM

The review found no eligible studies for this question.

1 finding from 1 review

Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical quinolone vs quinolones

Ear pain (otalgia) or discomfort or local irritation · people (of any age) with CSOM

The review found no eligible studies for this question.

1 finding from 1 review

Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical quinolone vs quinolones

Hearing · people (of any age) with CSOM

The review found no eligible studies for this question.

1 finding from 1 review

Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical quinolone vs quinolones

Serious complications · people (of any age) with CSOM

The review found no eligible studies for this question.

1 finding from 1 review

Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical quinolone vs quinolones

Suspected ototoxicity · people (of any age) with CSOM

1 finding from 1 review

Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 265 participants
Very low

Minocycline 45 mg vs minocycline 45 mg + azelaic acid gel

HRQOL ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Minocycline 45 mg vs minocycline 45 mg + azelaic acid gel

Participant‐assessed improvement in rosacea severity ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Minocycline 45 mg vs minocycline 45 mg + azelaic acid gel

Proportion of participants with adverse event · Participants with rosacea

Minocycline 45 mg showed no clear difference in proportion of participants with adverse event compared with minocycline 45 mg + azelaic acid gel (low certainty).

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
RR 0.69 [0.39, 1.22]
1 study · 60 participants
Low

Minocycline 45 mg vs minocycline 45 mg + azelaic acid gel

Physician‐assessed improvement in rosacea severity · Participants with rosacea

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Low

Minocycline 45 mg vs minocycline 45 mg + azelaic acid gel

Assessment of erythema or telangiectasia · Participants with rosacea

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Low

Minocycline 45 mg vs minocycline 45 mg + azelaic acid gel

Lesion count · Participants with rosacea

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Low