Cochrane · systematic review · CD013053
Topical versus systemic antibiotics for chronic suppurative otitis media
Chong, L-Y, Head, K, Webster, KE, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
ENTAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
21
current version
GRADE rated
10
No studies
11
Included studies
NR
No studies 11 · 52.4%Ungraded 0 · 0%Very low 9 · 42.9%Low 1 · 4.8%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Topical quinolone compared to oral quinolone for chronic suppurative otitis media
Population: people (of any age) with CSOM
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Resolution of ear discharge ‐ 1 to 2 weeks Topical quinolone vs oral quinolone | RR 1.48 [1.24, 1.76] | 3 studies · 285 participants | Low Downgraded: risk of bias |
Resolution of ear discharge ‐ after 4 weeks Topical quinolone vs oral quinolone | no estimate extracted | NR | No studies |
Health‐related quality of life Topical quinolone vs oral quinolone | no estimate extracted | NR | No studies |
Ear pain (otalgia) or discomfort or local irritation Topical quinolone vs oral quinolone | no estimate extracted | NR | No studies |
Hearing Topical quinolone vs oral quinolone | no estimate extracted | NR | No studies |
Serious complications Topical quinolone vs oral quinolone | no estimate extracted | NR | No studies |
Suspected ototoxicity Topical quinolone vs oral quinolone | no estimate extracted | 3 studies · 265 participants | Very low Downgraded: risk of bias, imprecision |
Topical quinolone compared to intramuscular gentamicin for chronic suppurative otitis media
Population: adults with CSOM
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Resolution of ear discharge at 1 to 2 weeks Topical quinolone vs intramuscular gentamicin | no estimate extracted | NR | No studies |
Resolution of ear discharge after 4 weeks Topical quinolone vs intramuscular gentamicin | no estimate extracted | NR | No studies |
Health‐related quality of life Topical quinolone vs intramuscular gentamicin | no estimate extracted | NR | No studies |
Ear pain (otalgia) or discomfort or local irritation Topical quinolone vs intramuscular gentamicin | no estimate extracted | 1 study · 60 participants | Very low Downgraded: imprecision |
Hearing Topical quinolone vs intramuscular gentamicin | no estimate extracted | 1 study · 60 participants | Very low Downgraded: imprecision |
Serious complications Topical quinolone vs intramuscular gentamicin | no estimate extracted | 1 study · 60 participants | Very low Downgraded: imprecision |
Suspected ototoxicity Topical quinolone vs intramuscular gentamicin | no estimate extracted | 1 study · 60 participants | Very low Downgraded: imprecision |
Topical quinolone compared to oral amoxicillin‐clavulanic acid combination for chronic suppurative otitis media
Population: adults with CSOM
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Resolution of ear discharge ‐ 1 to 2 weeks Topical quinolone vs oral amoxicillin‐clavulanic acid combination | RR 2.93 [1.5, 5.72] | 1 study · 56 participants | Very low Downgraded: risk of bias |
Resolution of ear discharge after 4 weeks Topical quinolone vs oral amoxicillin‐clavulanic acid combination | no estimate extracted | NR | No studies |
Health‐related quality of life Topical quinolone vs oral amoxicillin‐clavulanic acid combination | no estimate extracted | NR | No studies |
Ear pain (otalgia) or discomfort or local irritation Topical quinolone vs oral amoxicillin‐clavulanic acid combination | no estimate extracted | 1 study · 56 participants | Very low Downgraded: risk of bias |
Hearing Topical quinolone vs oral amoxicillin‐clavulanic acid combination | no estimate extracted | 1 study · 56 participants | Very low Downgraded: risk of bias |
Serious complications Topical quinolone vs oral amoxicillin‐clavulanic acid combination | no estimate extracted | NR | No studies |
Suspected ototoxicity Topical quinolone vs oral amoxicillin‐clavulanic acid combination | no estimate extracted | 1 study · 56 participants | Very low Downgraded: risk of bias |