Maternal infectious morbidity (chorioamnionitis and/or endometritis) ‐ Late induction of labour · pregnant women with prelabour rupture of membranes at or near term
It is very uncertain whether any antibiotic changes maternal infectious morbidity (chorioamnionitis and/or endometritis)… compared with placebo or no antibiotic (subgrouped by timing of induction of labour) (very low certainty).
1 finding from 1 review
Stillbirth · pregnant women with prelabour rupture of membranes at or near term
Any antibiotic showed no clear difference in stillbirth compared with placebo or no antibiotic (low certainty).
1 finding from 1 review
Perinatal mortality · pregnant women with prelabour rupture of membranes at or near term
Any antibiotic showed no clear difference in perinatal mortality compared with placebo or no antibiotic (low certainty).
1 finding from 1 review
Neonatal mortality · pregnant women with prelabour rupture of membranes at or near term
1 finding from 1 review
Adverse effects of antibiotics (skin rash) · Women who had normal vaginal births
It is very uncertain whether routine antibiotic prophylaxis changes adverse effects of antibiotics (skin rash) compared with no treatment or placebo (very low certainty).
1 finding from 1 review
New renal parenchymal defects (scars and thinning) on IVP: unit of analysis (children) at 4 to 5 years: surgical correction + antibiotics versus antibiotics alone · primary VUR
Surgical reimplantation of ureters plus antibiotics showed no clear difference in new renal parenchymal defects (scars and thinning) on IVP: unit of… compared with antibiotics alone (moderate certainty).
1 finding from 1 review
Correction of VUR: unit of analysis (children) after 3 years: surgical correction + antibiotics versus antibiotics alone · primary VUR
It is very uncertain whether surgical reimplantation of ureters plus antibiotics changes correction of VUR: unit of analysis (children) after 3 years:… compared with antibiotics alone (very low certainty).
1 finding from 1 review
Number of participants with symptomatic UTI · primary VUR
Surgical reimplantation of ureters plus antibiotics showed no clear difference in all symptomatic UTI by 4 to 5 years: surgical correction +… compared with antibiotics alone (moderate certainty).
1 finding from 1 review
Febrile UTI by 5 years: surgical correction + antibiotics versus antibiotics alone · primary VUR
Surgical reimplantation of ureters plus antibiotics probably leads to lower febrile UTI by 5 years: surgical correction + antibiotics versus… compared with antibiotics alone (moderate certainty).
1 finding from 1 review
Repeat positive urine culture · primary VUR
Surgical reimplantation of ureters plus antibiotics showed no clear difference in repeat positive urine cultures by 4 to 5 years: surgical correction… compared with antibiotics alone (moderate certainty).
1 finding from 1 review
Antibiotic resistance · people with bronchiectasis
28 days on/off antibiotic regimen leads to higher antibiotic resistance compared with 28 days on/off placebo regimen (high certainty).
1 finding from 1 review
OR 2.2 [1.42, 3.42]
Studies not reported
High
Antibiotic resistance · people with bronchiectasis
14 days on/off antibiotic regimen leads to higher antibiotic resistance compared with 14 days on/off placebo regimen (high certainty).
1 finding from 1 review
OR 2.14 [1.36, 3.35]
Studies not reported
High
Neonatal mortality ‐ oral antibiotic · neonates with sepsis
Comparison 1: route of antibiotic may leads to lower neonatal mortality ‐ oral antibiotic compared with standard care (low certainty).
1 finding from 1 review
Neonatal mortality ‐ injectable antibiotic · neonates with sepsis
Comparison 1: route of antibiotic probably leads to lower neonatal mortality ‐ injectable antibiotic compared with standard care (moderate certainty).
1 finding from 1 review
Neonatal mortality ‐ oral + injectable antibiotics · neonates with sepsis
Comparison 1: route of antibiotic showed no clear difference in neonatal mortality ‐ oral + injectable antibiotics compared with standard care (moderate certainty).
1 finding from 1 review
Active trachoma · people (any age) with active trachoma
Antibiotic may leads to lower active trachoma Clinical assessment: active trachoma defined as TF,… compared with control (low certainty).
1 finding from 1 review
Ocular chlamydia trachomatis infection · people (any age) with active trachoma
Antibiotic showed no clear difference in ocular C trachomatis infection Positive test for C trachomatis… compared with control (low certainty).
1 finding from 1 review
Adverse effects · people (any age) with active trachoma
Antibiotic may leads to lower adverse effects compared with control (low certainty).
1 finding from 1 review
Failure to induce clinical remission at end of study · Patients with active Crohn's disease
Antibiotic leads to lower failure to enter clinical remission compared with placebo (high certainty).
1 finding from 1 review
Failure to maintain remission · Patients with active Crohn's disease
Antibiotic showed no clear difference in failure to maintain clinical remission compared with placebo (low certainty).
1 finding from 1 review